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BACKGROUND AND AIMS: Alzheimer’s disease (AD) develops for decades, but the molecular mechanism of pathogenesis is poorly understood. In result, an effective AD cure is still missing. According to the cell cycle (CC) hypothesis, one of the AD causes is CC reactivation in mature neurons. We aimed at elucidation if similar CC alterations occur in AD brain neurons and in peripheral blood cells. METHODS:...
BACKGROUND AND AIMS: Alzheimer’s disease (AD) is the most common age-related dementia worldwide of unclear early pathogenesis. Mild Cognitive Impairment (MCI) represents an early AD stage, preceding massive deposition of Aβ aggregates and associated neuronal loss in the brain. Recently we demonstrated that sporadic AD (SAD) lymphoblasts show increased levels of p21 protein, the key regulator of G1/S...
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