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We investigated the associations between low density lipoprotein (LDL)-receptor gene haplotypes and lipid and lipoprotein levels in French-Canadian individuals with familial hypercholesterolemia (FH). The 112 unrelated patients studied shared the same < 10 Kb deletion in the 5 region of the LDL-receptor gene, leading to a null allele. Support for the hypothesis that the deletion is carried...
Evidence suggests that triglyceride-rich lipoprotein (TRL) remnants (REMs) play a significant role in the pathogenesis of atherosclerosis. Accurate methods to determine their plasma concentration have been lacking however, since REMs: a) are rapidly cleared from the circulation and are normally found at very low levels, and b) are difficult to distinguish from their TRL precursors. In the present...
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