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The challenging nature of complex human disorders has taught us that we can not untangle a disorder unless we understand how the ldquoenginerdquo of molecular systems works. After learning the basic physiology of different organs in the human body, a ldquomolecular revolutionrdquo occurred, which has now generated a huge amount of information regarding the function of individual molecules in human...
Systems biology envisions that the application of complex system engineering approaches to cell signaling molecular networks can lead to novel understandings of complex human disorders. In this paper we show that by developing biologically-driven vulnerability assessment methods, the vulnerability of complex signaling networks to the dysfunction of each molecule can be determined. We have analyzed...
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