Sachitanand M. Mali

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Activity‐Based Probes Developed by Applying a Sequential Dehydroalanine Formation Strategy to Expressed Proteins Reveal a Potential α‐Globin‐Modulating Deubiquitinase

Roman Meledin, Sachitanand M. Mali, Oded Kleifeld, Ashraf Brik

Angewandte Chemie International Edition > 57 > 20 > 5645 - 5649

We report a general and novel semisynthetic strategy for the preparation of ubiquitinated protein‐activity‐based probes on the basis of sequential dehydroalanine formation on expressed proteins. We applied this approach to construct a physiologically and therapeutically relevant ubiquitinated α‐globin probe, which was used for the enrichment and proteomic identification of α‐globin‐modulating deubiquitinases...

article

Activity‐Based Probes Developed by Applying a Sequential Dehydroalanine Formation Strategy to Expressed Proteins Reveal a Potential α‐Globin‐Modulating Deubiquitinase

Roman Meledin, Sachitanand M. Mali, Oded Kleifeld, Ashraf Brik

Angewandte Chemie > 130 > 20 > 5747 - 5751

We report a general and novel semisynthetic strategy for the preparation of ubiquitinated protein‐activity‐based probes on the basis of sequential dehydroalanine formation on expressed proteins. We applied this approach to construct a physiologically and therapeutically relevant ubiquitinated α‐globin probe, which was used for the enrichment and proteomic identification of α‐globin‐modulating deubiquitinases...

article

Convergent Versus Sequential Protein Synthesis: The Case of Ubiquitinated and Glycosylated H2B

Mallikanti Seenaiah, Muhammad Jbara, Sachitanand M. Mali, Ashraf Brik

Angewandte Chemie > 127 > 42 > 12551 - 12555

The chemical synthesis of a protein from four fragments or more applying native chemical ligation could be achieved stepwise, in one‐pot, convergently, or on a solid support. With the increasing demands of applying protein synthesis to highly complex targets, examining these approaches becomes essential to achieve highly efficient synthesis. Different chemical synthetic strategies are compared for...

article

Convergent Versus Sequential Protein Synthesis: The Case of Ubiquitinated and Glycosylated H2B

Mallikanti Seenaiah, Muhammad Jbara, Sachitanand M. Mali, Ashraf Brik

Angewandte Chemie International Edition > 54 > 42 > 12374 - 12378

The chemical synthesis of a protein from four fragments or more applying native chemical ligation could be achieved stepwise, in one‐pot, convergently, or on a solid support. With the increasing demands of applying protein synthesis to highly complex targets, examining these approaches becomes essential to achieve highly efficient synthesis. Different chemical synthetic strategies are compared for...

article

Synthesis and Structural Investigations of Functionalizable Hybrid β-Hairpin

Anupam Bandyopadhyay, Sachitanand M. Mali, Pooja Lunawat, K. Muruga Poopathi Raja, more

Organic Letters > 2011 > 13 > 17 > 4482 - 4485

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Search results for: Sachitanand M. Mali

Activity‐Based Probes Developed by Applying a Sequential Dehydroalanine Formation Strategy to Expressed Proteins Reveal a Potential α‐Globin‐Modulating Deubiquitinase

Activity‐Based Probes Developed by Applying a Sequential Dehydroalanine Formation Strategy to Expressed Proteins Reveal a Potential α‐Globin‐Modulating Deubiquitinase

Convergent Versus Sequential Protein Synthesis: The Case of Ubiquitinated and Glycosylated H2B

Convergent Versus Sequential Protein Synthesis: The Case of Ubiquitinated and Glycosylated H2B

Synthesis and Structural Investigations of Functionalizable Hybrid β-Hairpin

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INFONA - science communication portal

Search results for: Sachitanand M. Mali

Activity‐Based Probes Developed by Applying a Sequential Dehydroalanine Formation Strategy to Expressed Proteins Reveal a Potential α‐Globin‐Modulating Deubiquitinase

Activity‐Based Probes Developed by Applying a Sequential Dehydroalanine Formation Strategy to Expressed Proteins Reveal a Potential α‐Globin‐Modulating Deubiquitinase

Convergent Versus Sequential Protein Synthesis: The Case of Ubiquitinated and Glycosylated H2B

Convergent Versus Sequential Protein Synthesis: The Case of Ubiquitinated and Glycosylated H2B

Synthesis and Structural Investigations of Functionalizable Hybrid β-Hairpin

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