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Human α‐phosphoglucomutase 1 (α‐PGM) catalyzes the isomerization of glucose‐1‐phosphate into glucose‐6‐phosphate (G6P) through two sequential phosphoryl transfer steps with a glucose‐1,6‐bisphosphate (G16P) intermediate. Given that the release of G6P in the gluconeogenesis raises the glucose output levels, α‐PGM represents a tempting pharmacological target for type 2 diabetes. Here, we provide the...
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