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Neural simulation has been widely suggested as an alternative therapy for the treatment of medically-intractable seizures. Appropriate targeting of control stimuli at selected cortical locations may lead to seizure abatement. Neural population models describe the macroscopic neural activity that can be clinically recorded by an electroencephalogram (EEG). These models provide a safer way to develop...
Clinical evidence indicates that a third of patients with epilepsy are refractory to anti-epileptic drug treatment. For some of these patients better seizure control can be achieved by surgical treatment in which the seizure focus is localised and resected while avoiding injury to crucial cortical tissues. In this paper, non-seizure (interictal) epoch of electrographic recording was used to calculate...
Recent clinical and experimental evidence suggests that the spike-wave discharges (SWD) of absence seizures result from local activity within a hyperexcitable cortical region with rapid generalization through thalamocortical networks. The cortical focus is said to react more strongly to stimulation than other areas. We seek to develop a model which is in agreement with these recent experimental findings...
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