Search results for: Petri Heinonen

Items from 1 to 18 out of 18 results

article

5'‐O‐(2‐Isopropoxyprop‐2‐yl)‐protected Phosphoramidite Building Blocks in the Liquid Phase Oligonucleotide Synthesis

Zehong Liang, Petja Rosenqvist, Ella Pajuniemi, Mikko Ora, more

European Journal of Organic Chemistry > 26 > 36 > n/a - n/a

5'‐O‐(2‐isopropoxyprop‐2‐yl) (IIP)‐protection was introduced to 5’‐OH function of nucleosides in high yields by an acid‐catalysed transacetalization with 2,2‐diisopropoxypropane. The applicability of this temporal 5’‐O‐protecting group was demonstrated in the liquid phase oligonucleotide synthesis (LPOS) using the corresponding phosphoramidite building blocks (dA, dG, dC and dT) and a tetrapodal precipitative...

article

Temperature controlled stereoselectivity in the synthesis of 5-halo-2′-deoxyuridine derivatives

Tom Lagerwall, Petri Heinonen, Mikko Oivanen

Tetrahedron Letters > 2015 > 56 > 43 > 5950-5953

A series of α- and β-5-halo-2′-deoxyuridine derivatives were prepared with high anomeric selectivity using the conventional silylbase glycosylation method and taking advantage of the 3′-O-(N-acetyl)glycyl protection group and temperature control. Reactions performed at −7°C gave as much as 87% of the β-anomers, while an overnight reaction at 30°C gave up to 95% of the α-anomers.

article

Isomerization and Decomposition of a Criegee Intermediate in the Ozonolysis of Alkenes: Dynamics Using a Multireference Potential

Jaroslaw Kalinowski, Markku Räsänen, Petri Heinonen, Ilkka Kilpeläinen, more

Angewandte Chemie > 126 > 1 > 269 - 272

The isomerization and decomposition dynamics of the simplest Criegee intermediate CH₂OO have been studied by classical trajectory simulations using the multireference ab initio MR‐PT2 potential on the fly. A new, accelerated algorithm for dynamics with MR‐PT2 was used. For an initial temperature of 300 K, starting from the transition state from CH₂OO→CH₂O₂ , the system reaches the dioxirane structure...

article

Isomerization and Decomposition of a Criegee Intermediate in the Ozonolysis of Alkenes: Dynamics Using a Multireference Potential

Jaroslaw Kalinowski, Markku Räsänen, Petri Heinonen, Ilkka Kilpeläinen, more

Angewandte Chemie International Edition > 53 > 1 > 265 - 268

chapter

A visualization and modeling tool for security metrics and measurements management

Reijo M. Savola, Petri Heinonen

2011 Information Security for South Africa > 1 - 8

2011 Information Security for South Africa (ISSA)

Sufficient and credible information security measurement in software-intensive systems requires use of a variety of security metrics offering security-related evidence from different viewpoints. Visualization is needed to facilitate management of security metrics and measurements and to increase the meaningfulness of them in decision-making such as security assurance and risk management. We introduce...

article

Is coproporphyrin III a copper-acquisition compound in Paracoccus denitrificans?

Jani Anttila, Petri Heinonen, Timo Nenonen, Andrea Pino, more

BBA - Bioenergetics > 2011 > 1807 > 3 > 311-318

Paracoccus denitrificans is a soil bacterium which can respire aerobically and also denitrify if oxygen is absent. Both processes are highly dependent on copper enzymes and copper is therefore likely to be an essential trace element for the bacterium. If copper is not easily available, a copper-acquisition mechanism would be highly beneficial. In this paper, we have addressed the question of whether...

chapter

Security-Measurability-Enhancing Mechanisms for a Distributed Adaptive Security Monitoring System

Reijo M Savola, Petri Heinonen

2010 Fourth International Conference on Emerging Security Information, Systems and Technologies > 25 - 34

2010 Fourth International Conference on Emerging Security Information, Systems and Technologies (SECURWARE)

Adaptive security management enables resilience, self-protection and self-healing functionality in business-critical applications, their platforms and networks. Sufficient and credible security evidence gathered from the system and its use forms the basis for adaptive security decision-making. This study proposes practical and systematic security-measurability-enhancing mechanisms that support adaptive...

article

On the Reactions of Two Fungal Laccases Differing in Their Redox Potential with Lignin Model Compounds: Products and Their Rate of Formation

Maarit Lahtinen, Kristiina Kruus, Petri Heinonen, Jussi Sipilä

Journal of Agricultural and Food Chemistry > 2009 > 57 > 18 > 8357 - 8365

article

Oligonucleotides bearing pentaerythritol-derived mass tags

Anu Kiviniemi, Petri Heinonen, Harri Lönnberg

Open Chemistry > 2007 > 5 > 1 > 191-200

Five different di-O-alkylated pentaerythritol phosphoramidite building blocks (2a–e) were synthesized and introduced into oligonucleotides to obtain mass-tagged probes (6a–f) useful in RNA transcription profiling. These non-nucleosidic mass tags allow categorization of oligonucleotide probes having identical nucleoside content and, hence, identification of the probe hybridized to RNA by mass spectrometry...

article

Oligonucleotides bearing pentaerythritol-derived mass tags

Anu Kiviniemi, Petri Heinonen, Harri Lönnberg

Open Chemistry > 2007 > 5 > 1 > 191-200

article

Oligonucleotides bearing pentaerythritol-derived mass tags

Anu Kiviniemi, Petri Heinonen, Harri Lönnberg

Central European Journal of Chemistry > 2007 > 5 > 1 > 191-200

Five different di-O-alkylated pentaerythritol phosphoramidite building blocks (2a–e) were synthesized and introduced into oligonucleotides to obtain mass-tagged probes (6a–f) useful in RNA transcription profiling. These non-nucleosidic mass tags allow categorization of oligonucleotide probes having identical nucleoside content and, hence, identification of the probe hybridized to RNA by mass spectrometry...

article

2,2-Bis(ethoxycarbonyl)- and 2-(Alkylaminocarbonyl)-2-cyano-Substituted 3-(Pivaloyloxy)propyl Groups as Biodegradable Phosphate Protections of Oligonucleotides

Päivi Poijärvi, Petri Heinonen, Pasi Virta, Harri Lönnberg

Bioconjugate Chemistry > 2005 > 16 > 6 > 1564 - 1571

article

Synthesis of Phosphate-Branched Oligonucleotides

Petri Heinonen, Harri Lönnberg

Bioconjugate Chemistry > 2004 > 15 > 6 > 1158 - 1160

article

Solid-Phase Synthesis of Oligonucleotide Glycoconjugates Bearing Three Different Glycosyl Groups: Orthogonally Protected Bis(hydroxymethyl)- N,N ‘ -bis(3-hydroxypropyl)malondiamide Phosphoramidite as Key Building Block

Johanna Katajisto, Petri Heinonen, Harri Lönnberg

The Journal of Organic Chemistry > 2004 > 69 > 22 > 7609 - 7615

article

Facile Determination of the Protecting Group Location of N ⁱ ^m -Protected Histidine Derivatives by ¹ H− ¹⁵ N Heteronuclear Correlation NMR

Simone Zaramella, Petri Heinonen, Esther Yeheskiely, Roger Strömberg

The Journal of Organic Chemistry > 2003 > 68 > 19 > 7521 - 7523

article

An Orthogonally Protected α , α -Bis(aminomethyl)- β - alanine Building Block for the Construction of Glycoconjugates on a Solid Support

Johanna Katajisto, Tuomas Karskela, Petri Heinonen, Harri Lönnberg

The Journal of Organic Chemistry > 2002 > 67 > 23 > 7995 - 8001

article

Synthesis of Achiral α,α-Disubstituted β-Alanines, and Their Use in Construction of Libraries of β-Peptide Conjugates of N-2-alkyl-1,2,3,4-Tetrahydroisoquinolines on a Solid Support

Petri Heinonen, Pasi Virta, Harri Lönnberg

Tetrahedron > 1999 > 55 > 24 > 7613-7624

Six achiral N-phthaloyl protected α,α-disubstituted β-amino acids were synthesized, and used to construct a 96 compound library of 1,2,3,4-tetrahydroisoquinoline conjugates of β-peptides on a solid support. The library synthesis consisted of attachment of an appropriately 5-O-tethered 1,2,3,4-tetrahydroisoquinoline via the N-2 atom to a vinyl sulfonyl support, elongation of the deprotected 5-O-tether...

article

A Novel Solid Support for Derivatization and Subsequent N-Alkylation of Secondary Amines: Preparation of N-Alkylated 5- and 6-Alkoxy-1,2,3,4-tetrahydroisoquinolines via Mitsunobu Reaction

Petri Heinonen, Harri Lönnberg

Tetrahedron Letters > 1997 > 38 > 49 > 8569-8572

A hydroxymethylated polystyrene resin has been converted to its vinylsulfonylethyl ether (1) by DBU catalyzed addition of the hydroxy groups to divinyl sulfone. The support obtained was used to convert 5- and 6-(tetrahydropyran-2-yloxy)-1,2,3,4-tetrahydroisoquinolines to a set of N-alkylated tetrahydroisoquinolines bearing various 5- and 6-alkoxy substituents (5a-m). The synthesis involved attachment...

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