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Wohldefiniert modifiziert: Die Anwendung der bakteriellen Transglutaminase ermöglicht die ortsspezifische Modifikation von Glutaminseitenketten tumorgerichteter Antikörper mit verschiedenen Lysin‐ähnlichen Sonden. Die Methode führt zu homogenen Immunkonjugaten mit definiertem stöchiometrischem Verhältnis. Vergleichenden In‐vivo‐Studien in xenotransplantierten Mäusen zufolge weisen die enzymatisch...
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