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Herein, we describe the synthesis of Pyk2 inhibitors via macrocyclization of FAK and dual Pyk2-FAK inhibitors. We identified macrocycle 25a as a highly potent Pyk2 inhibitor (IC50=0.7nM), with ∼175-fold improvement in Pyk2 potency as compared to its acyclic counterpart. In many cases, macrocyclization improved Pyk2 potency while weakening FAK potency, thereby improving the Pyk2/FAK selectivity ratio...
Floating gate material plays a significant role in the performance of Electrically Erasable Programmable Read-only memory (EEPROM). In this work, three types of floating gate Si materials were utilized for fabricated EEPROM cells. In-situ doped amorphous Si shows better high temperature data retention (HTDR) performance than both poly crystalline Si and amorphous Si with post-deposition implantation...
One of the key challenges in embedded memory solutions is yield degradation due to additional thermal budget in the process. In this work, we report STI HDP-CVD (Shallow Trench Isolation High-Density Plasma Chemical Vapor Deposition) process as a key contribution factor to yield degradation in embedded memory devices by causing higher degree of silicon dislocations. With optimized plasma sputter/deposition...
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