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Conantokin-R (con-R) is a γ-carboxyglutamate-containing 27-residue neuroactive peptide present in the venom of Conus radiatus, and acts as a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. This peptide features a single disulfide bond, a type of structural element found in most classes of conotoxins, but not in other conantokins. The NMDA receptor antagonist activity of chemically...
A series of variants of the neuroactive 17-residue γ-carboxyglutamate-(Gla)-containing polypeptide, conantokin-G (con-G), were synthesized with the intention of determining those features that were important for its N-methyl-d-aspartate (NMDA) receptor-targeted antagonist activity and for adoption of its divalent cation-dependent α-helical conformation. Employing the binding of [ 3 H]dizolcipine...
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