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In this study, we developed a novel synthesis method to create a complex collagen-based biopolymer that promises to possess the necessary material properties for a bone graft substitute. The synthesis was carried out in several steps. In the first step, a ring-opening polymerization reaction initiated by hydroxyapatite nanoparticles was used to polymerize d,l-lactide and glycolide monomers to form...
Sickle red blood cell (SRBC) adherence to endothelial cells (EC) contributes to microvascular occlusion and ischemic pain characteristic of sickle cell anemia. SRBC adherence to EC is complex and involves EC and SRBC receptors and adhesive proteins. To date, four distinct adherence pathways have been described. Here, biophysical detachment assays were utilized to quantify the tenacity of SRBC adherence...
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