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The male Fischer 344 rat is an established model to study progressive renal dysfunction that is similar, but not identical, to chronic kidney disease (CKD) in humans. These studies were designed to assess age-dependent alterations in renal structure and function at late-life timepoints, 16–24 months. Elevations in BUN and plasma creatinine were not significant until 24 months, however, elevations...
Fibrinogen, the major blood-clotting protein, is made up of three chains, Aα, Bβ and γ, which are synthesized and secreted by the liver. In this communication, we describe the complete cDNA sequence, deduced amino acid (aa) sequence and organization of the gene encoding the Bβ subunit of fibrinogen from Xenopus laevis (Xl). The cDNA representing the predominant form of the Bβ mRNA comprises 2390...
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