Photo‐control of affinity reagents offers a general approach for high‐resolution spatiotemporal control of diverse molecular processes. In an effort to develop general design principles for a photo‐controlled affinity reagent, we took a structure‐based approach to the design of a photoswitchable Z‐domain, among the simplest of affinity reagent scaffolds. A chimera, designated Z‐PYP, of photoactive...
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