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We previously demonstrated that the substitution of the autolysis loop (residues 143–154 in chymotrypsin numbering) of APC with the corresponding loop of trypsin (APC-Tryp 143–154 ) has no influence on the proteolytic activity of the protease toward fVa, however, this substitution increases the reactivity of APC with plasma inhibitors so that the mutant exhibits no anticoagulant activity in...
Thrombomodulin (TM) is as essential cofactor in protein C activation by thrombin. To investigate the cofactor effect of TM on the P3-P3′ binding specificity of thrombin, we prepared a Gla-domainless protein C (GDPC) and an antithrombin (AT) mutant in which the P3-P3′ residues of both molecules were replaced with the corresponding residues of the factor Xa cleavage site in prethrombin-2. TM is known...
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