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The mitotic spindle has proven to be an effective therapeutic target in antineoplastic efforts. In this study, we sought to assess the efficacy of ispinesib, a mitotic kinesin spindle protein (KSP) inhibitor in androgen-independent prostate cancer progressing after docetaxel. Patients were treated with ispinesib 18 mg/m 2 every 21 days and assessed for prostate-specific antigen (PSA) and...
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