Search results for: John-Stephen Taylor

Items from 1 to 20 out of 37 results

article

Adjacent and Nonadjacent Dipyrimidine Photoproducts as Intrinsic Probes of DNA Secondary and Tertiary Structure^†

John‐Stephen Taylor

Photochemistry and Photobiology > 99 > 2 > 277 - 295

While the photochemistry of duplex DNA has been extensively studied, the photochemistry of nonduplex DNA structures is largely unexplored. Because the structure and stereochemistry of DNA photoproducts depend on the secondary structure and conformation of the DNA precursor, they can serve as intrinsic probes of DNA structure. This review focuses on the structures and stereoisomers of pyrimidine dimer...

article

Ability of the Putative Decomposition Products of 2,3‐dioxetanes of Indoles to Photosensitize Cyclobutane Pyrimidine Dimer (CPD) Formation and its Implications for the “Dark” (Chemisensitized) Pathway to CPDs in Melanocytes^†

Yanjing Wang, Elena M. Cacchillo, Dariusz M. Niedzwiedzki, John‐Stephen Taylor

Photochemistry and Photobiology > 98 > 2 > 442 - 454

The formation of cyclobutane pyrimidine dimers (CPDs) by a “dark” pathway in melanocytes has been attributed to chemisensitization by dioxetanes produced from peroxynitrite oxidation of melanin or melanin precursors. These dioxetanes are proposed to decompose to triplet state compounds which sensitize CPD formation by triplet–triplet energy transfer. To determine whether such compounds are capable...

article

Photocrosslinking of G‐Quadruplex‐Forming Sequences found in Human Promoters

Jillian E. Smith‐Carpenter, John‐Stephen Taylor

Photochemistry and Photobiology > 95 > 1 > 252 - 266

While is it well known that human telomeric DNA sequences can adopt G‐quadruplex structures, some promoters sequences have also been found to form G‐quadruplexes, and over 40% of promoters contain putative G‐quadruplex‐forming sequences. Because UV light has been shown to crosslink human telomeric G‐quadruplexes by cyclobutane pyrimidine dimer (CPD) formation between T's on adjacent loops, UV light...

article

Design, synthesis, and characterization of nucleosomes containing site-specific DNA damage

John-Stephen Taylor

DNA Repair > 2015 > 36 > C > 59-67

How DNA damaged is formed, recognized, and repaired in chromatin is an area of intense study. To better understand the structure activity relationships of damaged chromatin, mono and dinucleosomes containing site-specific damage have been prepared and studied. This review will focus on the design, synthesis, and characterization of model systems of damaged chromatin for structural, physical, and enzymatic...

article

Biotinylated quercetin as an intrinsic photoaffinity proteomics probe for the identification of quercetin target proteins

Rongsheng E. Wang, Clayton R. Hunt, Jiawei Chen, John-Stephen Taylor

Bioorganic & Medicinal Chemistry > 2011 > 19 > 16 > 4710-4720

Quercetin is a flavonoid natural product, that is, found in many foods and has been found to have a wide range of medicinal effects. Though a number of quercetin binding proteins have been identified, there has been no systematic approach to identifying all potential targets of quercetin. We describe an O7-biotinylated derivative of quercetin (BioQ) that can act as a photoaffinity proteomics reagent...

article

Identification of Critical Residues for the Tight Binding of Both Correct and Incorrect Nucleotides to Human DNA Polymerase λ

Jessica A. Brown, Lindsey R. Pack, Shanen M. Sherrer, Ajay K. Kshetry, more

Journal of Molecular Biology > 2010 > 403 > 4 > 505-515

DNA polymerase λ (Pol λ) is a novel X-family DNA polymerase that shares 34% sequence identity with DNA polymerase β. Pre-steady-state kinetic studies have shown that the Pol λ–DNA complex binds both correct and incorrect nucleotides 130-fold tighter, on average, than the DNA polymerase β–DNA complex, although the base substitution fidelity of both polymerases is 10 ⁻ ⁴ to 10 ⁻⁵ ...

article

DNA polymerase β-dependent long patch base excision repair in living cells

Kenjiro Asagoshi, Yuan Liu, Aya Masaoka, Li Lan, more

DNA Repair > 2010 > 9 > 2 > 109-119

We examined a role for DNA polymerase β (Pol β) in mammalian long patch base excision repair (LP BER). Although a role for Pol β is well known in single-nucleotide BER, information on this enzyme in the context of LP BER has been limited. To examine the question of Pol β involvement in LP BER, we made use of nucleotide excision repair-deficient human XPA cells expressing UVDE (XPA-UVDE), which introduces...

article

Acceleration of 5-Methylcytosine Deamination in Cyclobutane Dimers by G and Its Implications for UV-Induced C-to-T Mutation Hotspots

Vincent J. Cannistraro, John-Stephen Taylor

Journal of Molecular Biology > 2009 > 392 > 5 > 1145-1157

Sunlight-induced C→T mutation hotspots occur most frequently at methylated CpG sites in tumor suppressor genes and are thought to arise from translesion synthesis past deaminated cyclobutane pyrimidine dimers (CPDs). While it is known that methylation enhances CPD formation in sunlight, little is known about the effect of methylation and sequence context on the deamination of 5-methylcytosine ( ...

article

Inhibition of Heat Shock Induction of Heat Shock Protein 70 and Enhancement of Heat Shock Protein 27 Phosphorylation by Quercetin Derivatives

Rongsheng E. Wang, Jeffrey L.-F. Kao, Carolyn A. Hilliard, Raj K. Pandita, more

Journal of Medicinal Chemistry > 2009 > 52 > 7 > 1912 - 1921

article

Synthesis of Peptide Nucleic Acid FRET Probes via an Orthogonally Protected Building Block for Post-Synthetic Labeling of Peptide Nucleic Acids at the 5-Position of Uracil

Bereket Y. Oquare, John-Stephen Taylor

Bioconjugate Chemistry > 2008 > 19 > 11 > 2196 - 2204

article

Evidence That the (6−4) Photolyase Mechanism Can Proceed through an Oxetane Intermediate

Saâdia Asgatay, Christian Petermann, Dominique Harakat, Dominique Guillaume, more

Journal of the American Chemical Society > 2008 > 130 > 38 > 12618 - 12619

article

Use of Multiple Carboxylates to Increase Intracellular Retention of Fluorescent Probes Following Release From Cell Penetrating Fluorogenic Conjugates

Xiaoxu Li, Ryuji Higashikubo, John-Stephen Taylor

Bioconjugate Chemistry > 2008 > 19 > 1 > 50 - 56

article

Mechanism of Template-independent Nucleotide Incorporation Catalyzed by a Template-dependent DNA Polymerase

Kevin A. Fiala, Jessica A. Brown, Hong Ling, Ajay K. Kshetry, more

Journal of Molecular Biology > 2007 > 365 > 3 > 590-602

Numerous template-dependent DNA polymerases are capable of catalyzing template-independent nucleotide additions onto blunt-end DNA. Such non-canonical activity has been hypothesized to increase the genomic hypermutability of retroviruses including human immunodeficiency viruses. Here, we employed pre-steady state kinetics and X-ray crystallography to establish a mechanism for blunt-end additions catalyzed...

article

DNA Synthesis Past a 5-MethylC-Containing cis - syn -Cyclobutane Pyrimidine Dimer by Yeast Pol η Is Highly Nonmutagenic ^†

Bich Vu, Vincent J. Cannistraro, Liping Sun, John Stephen Taylor

Biochemistry > 2006 > 45 > 30 > 9327 - 9335

article

Synthesis and Characterization of a [3- ¹⁵ N]-Labeled Cis-Syn Thymine Dimer-Containing DNA Duplex

Hussam M. Bdour, Jeff Lung-Fa Kao, John-Stephen Taylor

The Journal of Organic Chemistry > 2006 > 71 > 4 > 1640 - 1646

article

MicroPET Imaging of MCF-7 Tumors in Mice via unr mRNA-Targeted Peptide Nucleic Acids

Xiankai Sun, Huafeng Fang, Xiaoxu Li, Raffaella Rossin, more

Bioconjugate Chemistry > 2005 > 16 > 2 > 294 - 305

article

Evidence for Watson−Crick and Not Hoogsteen or Wobble Base Pairing in the Selection of Nucleotides for Insertion Opposite Pyrimidines and a Thymine Dimer by Yeast DNA Pol η ^†

Hanshin Hwang, John-Stephen Taylor

Biochemistry > 2005 > 44 > 12 > 4850 - 4860

article

Improved Nucleic Acid Triggered Probe Activation through the Use of a 5-Thiomethyluracil Peptide Nucleic Acid Building Block

Jianfeng Cai, Xiaoxu Li, John Stephen Taylor

Organic Letters > 2005 > 7 > 5 > 751 - 754

article

Nucleic Acid-Triggered Fluorescent Probe Activation by the Staudinger Reaction

Jianfeng Cai, Xiaoxu Li, Xuan Yue, John Stephen Taylor

Journal of the American Chemical Society > 2004 > 126 > 50 > 16324 - 16325

article

Role of Base Stacking and Sequence Context in the Inhibition of Yeast DNA Polymerase η by Pyrene Nucleotide ^†

Hanshin Hwang, John-Stephen Taylor

Biochemistry > 2004 > 43 > 46 > 14612 - 14623

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INFONA - science communication portal

Search results for: John-Stephen Taylor

Adjacent and Nonadjacent Dipyrimidine Photoproducts as Intrinsic Probes of DNA Secondary and Tertiary Structure^†

Ability of the Putative Decomposition Products of 2,3‐dioxetanes of Indoles to Photosensitize Cyclobutane Pyrimidine Dimer (CPD) Formation and its Implications for the “Dark” (Chemisensitized) Pathway to CPDs in Melanocytes^†

Photocrosslinking of G‐Quadruplex‐Forming Sequences found in Human Promoters

Design, synthesis, and characterization of nucleosomes containing site-specific DNA damage

Biotinylated quercetin as an intrinsic photoaffinity proteomics probe for the identification of quercetin target proteins

Identification of Critical Residues for the Tight Binding of Both Correct and Incorrect Nucleotides to Human DNA Polymerase λ

DNA polymerase β-dependent long patch base excision repair in living cells

Acceleration of 5-Methylcytosine Deamination in Cyclobutane Dimers by G and Its Implications for UV-Induced C-to-T Mutation Hotspots

Inhibition of Heat Shock Induction of Heat Shock Protein 70 and Enhancement of Heat Shock Protein 27 Phosphorylation by Quercetin Derivatives

Synthesis of Peptide Nucleic Acid FRET Probes via an Orthogonally Protected Building Block for Post-Synthetic Labeling of Peptide Nucleic Acids at the 5-Position of Uracil

Evidence That the (6−4) Photolyase Mechanism Can Proceed through an Oxetane Intermediate

Use of Multiple Carboxylates to Increase Intracellular Retention of Fluorescent Probes Following Release From Cell Penetrating Fluorogenic Conjugates

Mechanism of Template-independent Nucleotide Incorporation Catalyzed by a Template-dependent DNA Polymerase

DNA Synthesis Past a 5-MethylC-Containing cis - syn -Cyclobutane Pyrimidine Dimer by Yeast Pol η Is Highly Nonmutagenic ^†

Synthesis and Characterization of a [3- ¹⁵ N]-Labeled Cis-Syn Thymine Dimer-Containing DNA Duplex

MicroPET Imaging of MCF-7 Tumors in Mice via unr mRNA-Targeted Peptide Nucleic Acids

Evidence for Watson−Crick and Not Hoogsteen or Wobble Base Pairing in the Selection of Nucleotides for Insertion Opposite Pyrimidines and a Thymine Dimer by Yeast DNA Pol η ^†

Improved Nucleic Acid Triggered Probe Activation through the Use of a 5-Thiomethyluracil Peptide Nucleic Acid Building Block

Nucleic Acid-Triggered Fluorescent Probe Activation by the Staudinger Reaction

Role of Base Stacking and Sequence Context in the Inhibition of Yeast DNA Polymerase η by Pyrene Nucleotide ^†

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