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CYP17 (17α-hydroxylase-17,20-lyase; also P450c17 or P450 17α ) catalyses the17α-hydroxylation of progestogens and the subsequent acyl-carbon cleavage of the 17α-hydroxylated products (lyase activity) in the biosynthesis of androgens. The enzyme also catalyses another type of acyl-carbon cleavage (direct cleavage activity) in which the 17α-hydroxylation reaction is by-passed. Human CYP17 is...
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