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Ribavirin is the first synthetic, broad-spectrum antiviral nucleoside. Despite its more than 30 year history, the mechanism of action of this compound remains unclear and somewhat controversial. Recent data suggest the possibility that the activity of ribavirin against RNA viruses is a reflection of incorporation of ribavirin into the viral genome. Because ribavirin incorporation is not specific,...
Hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp) has acquired a unique β-hairpin in the thumb subdomain which protrudes toward the active site. We report here that this β-hairpin plays an important role in positioning the 3′ terminus of the viral RNA genome for correct initiation of replication. The presence of this β-hairpin interferes with polymerase binding...
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