Search results for: Lawrence J. Dangott

Items from 1 to 13 out of 13 results

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Tu1263 - Alterations in the Proteomic, Microbiome, and Metabolomic Profile in Cats with Inflammatory Bowel Disease and Enteropathy-Associated T-Cell Lymphoma type 2

Sina Marsilio, Lawrence J. Dangott, Jonathan A. Lidbury, Jan S. Suchodolski, more

Gastroenterology > 2018 > 154 > 6(S1) > S-918

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Polysaccharide associated protein (PSAP) from the green microalga Botryococcus braunii is a unique extracellular matrix hydroxyproline-rich glycoprotein

Mehmet Tatli, Mayumi Ishihara, Christian Heiss, Daniel R. Browne, more

Algal Research > 2018 > 29 > C > 92-103

The green colonial microalga Botryococcus braunii produces large amounts of liquid hydrocarbons that can be converted into transportation fuels. Colony cells are held together by a complex extracellular matrix (ECM) made up of a cross-linked long-chain hydrocarbon network around which liquid hydrocarbons are stored, a retaining wall for holding hydrocarbons within the cross-linked hydrocarbon network,...

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Fabp1 gene ablation inhibits high‐fat diet‐induced increase in brain endocannabinoids

Gregory G. Martin, Danilo Landrock, Sarah Chung, Lawrence J. Dangott, more

Journal of Neurochemistry > 140 > 2 > 294 - 306

The endocannabinoid system shifts energy balance toward storage and fat accumulation, especially in the context of diet‐induced obesity. Relatively little is known about factors outside the central nervous system that may mediate the effect of high‐fat diet (HFD) on brain endocannabinoid levels. One candidate is the liver fatty acid binding protein (FABP1), a cytosolic protein highly prevalent in...

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Female Mice are Resistant to Fabp1 Gene Ablation-Induced Alterations in Brain Endocannabinoid Levels

Gregory G. Martin, Sarah Chung, Danilo Landrock, Kerstin K. Landrock, more

Lipids > 2016 > 51 > 9 > 1007-1020

Although liver fatty acid binding protein (FABP1, L-FABP) is not detectable in the brain, Fabp1 gene ablation (LKO) markedly increases endocannabinoids (EC) in brains of male mice. Since the brain EC system of females differs significantly from that of males, it was important to determine if LKO differently impacted the brain EC system. LKO did not alter brain levels of arachidonic acid (ARA)-containing...

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Fatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias

Friedhelm Schroeder, Avery L. McIntosh, Gregory G. Martin, Huan Huang, more

Lipids > 2016 > 51 > 6 > 655-676

The first discovered member of the mammalian FABP family, liver fatty acid binding protein (FABP1, L-FABP), occurs at high cytosolic concentration in liver, intestine, and in the case of humans also in kidney. While the rat FABP1 is well studied, the extent these findings translate to human FABP1 is not clear—especially in view of recent studies showing that endocannabinoids and cannabinoids represent...

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Differential protein expression in the nucleus accumbens of high and low active mice

David P. Ferguson, Lawrence J. Dangott, Heather L. Vellers, Emily E. Schmitt, more

Behavioural Brain Research > 2015 > 291 > Complete > 283-288

Physical inactivity is associated with the development of a variety of chronic illnesses. Literature has shown that physical activity is genetically regulated; however there is limited information on the mechanisms that influence this process with existing studies primarily focused on genomic and/or transcription association studies. There have been no studies to determine differential protein expression...

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Rescue of the Orphan Enzyme Isoguanine Deaminase

Daniel S. Hitchcock, Alexander A. Fedorov, Elena V. Fedorov, Lawrence J. Dangott, more

Biochemistry > 2011 > 50 > 25 > 5555 - 5557

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Proteomic analysis of urine from male dogs during early stages of tubulointerstitial injury in a canine model of progressive glomerular disease

Mary B. Nabity, George E. Lees, Lawrence J. Dangott, Rachel Cianciolo, more

Veterinary Clinical Pathology > 40 > 2 > 222 - 236

Background: Sensitive and specific noninvasive biomarkers for tubulointerstitial injury are lacking, and proteomic techniques provide a powerful tool for biomarker discovery. Objective: The aim of this study was to identify novel urinary biomarkers of early tubulointerstitial injury in canine progressive renal disease using both 2‐dimensional differential in‐gel electrophoresis (2‐D DIGE), which...

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Expression and purification of biologically active Trichoderma virens proteinaceous elicitor Sm1 in Pichia pastoris

Natthiya Buensanteai, Prasun K. Mukherjee, Benjamin A. Horwitz, Cheng Cheng, more

Protein Expression and Purification > 2010 > 72 > 1 > 131-138

The beneficial fungus Trichoderma virens secretes a small cysteine-rich protein (Sm1) that induces defense responses in dicot and monocot plants and is a member of the cerato-platanin family. Purification of Sm1 from T. virens results in low protein yield limiting the application of this protein for crop disease protection to small-scale assays. To increase the yield of Sm1, we cloned the sm1 gene...