Search results for: Songpon Deechongkit

Items from 1 to 13 out of 13 results

article

Molecular dynamics investigation of psalmopeotoxin I. Probing the relationship between 3D structure, anti-malarial activity and thermal stability

Matthew Paul Gleeson, Songpon Deechongkit, Somsak Ruchirawat

Journal of Molecular Modeling > 2011 > 17 > 4 > 769-775

PcFK1 is a member of the cysteine knot inhibitor family that displays anti-malarial properties. The naturally occurring molecule is ∼40 amino acids in length and forms a highly constrained 3D structure due to the presence of 3 disulfide and multiple intra-molecular H-bonds. Recent experimental studies on PcFK1 wild-type and mutants, where the cystiene residues of each disulfide bond were mutated into...

article

Synthesis, biophysical, and biological studies of wild-type and mutant psalmopeotoxins—Anti-malarial cysteine knot peptides from Psalmopoeus cambridgei

Pacharin Kamolkijkarn, Thitawan Prasertdee, Chawita Netirojjanakul, Pakornwit Sarnpitak, more

Peptides > 2010 > 31 > 4 > 533-540

Psalmopeotoxin I and II (PcFK1 and PcFK2), an anti-malarial peptide first extracted from Psalmopoeus cambridgei was synthesized and characterized. Both peptides belong to the Inhibitor Cystine Knot (ICK) superfamily, containing three disulfide bridges. The six cysteine residues are conserved similar to other members of the ICK superfamily, suggesting their critical role for either folding or function...

article

β-Sheet folding mechanisms from perturbation energetics

Songpon Deechongkit, Houbi Nguyen, Marcus Jager, Evan T Powers, more

Current Opinion in Structural Biology > 2006 > 16 > 1 > 94-101

Amide backbone and sidechain mutagenesis data can be used in combination with kinetic and thermodynamic measurements to understand the energetic contributions of backbone hydrogen bonding and the hydrophobic effect to the acquisition of β-sheet structure. For example, it has been revealed that loop 1 of the WW domain forms in the transition state, consistent with the emerging theme that reverse turn...

article

Controlling the Morphology of Cross β-Sheet Assemblies by Rational Design

Songpon Deechongkit, Evan T. Powers, Shu-Li You, Jeffery W. Kelly

Journal of the American Chemical Society > 2005 > 127 > 23 > 8562 - 8570

article

Toward Assessing the Position-Dependent Contributions of Backbone Hydrogen Bonding to β-Sheet Folding Thermodynamics Employing Amide-to-Ester Perturbations

Songpon Deechongkit, Philip E. Dawson, Jeffery W. Kelly

Journal of the American Chemical Society > 2004 > 126 > 51 > 16762 - 16771

article

Solid-Phase Synthesis and Stereochemical Assignments of Tenuecyclamides A−D Employing Heterocyclic Amino Acids Derived from Commercially Available Fmoc α-Amino Acids

Shu-Li You, Songpon Deechongkit, Jeffery W. Kelly

Organic Letters > 2004 > 6 > 15 > 2627 - 2630

article

Synthesis of All Nineteen Appropriately Protected Chiral α-Hydroxy Acid Equivalents of the α-Amino Acids for Boc Solid-Phase Depsi-Peptide Synthesis

Songpon Deechongkit, Shu-Li You, Jeffery W. Kelly

Organic Letters > 2004 > 6 > 4 > 497 - 500

article

Recombinant Expression, Purification, and Comparative Characterization of TorsinA and Its Torsion Dystonia-Associated Variant ΔE-TorsinA ^†

Karen Kustedjo, Songpon Deechongkit, Jeffery W. Kelly, Benjamin F. Cravatt

Biochemistry > 2003 > 42 > 51 > 15333 - 15341

article

Synthesis of a Negatively Charged Dibenzofuran-Based β-Turn Mimetic and Its Incorporation into the WW Miniprotein-Enhanced Solubility without a Loss of Thermodynamic Stability

Ramesh Kaul, Songpon Deechongkit, Jeffery W. Kelly

Journal of the American Chemical Society > 2002 > 124 > 40 > 11900 - 11907

article

The Effect of Backbone Cyclization on the Thermodynamics of β -Sheet Unfolding: Stability Optimization of the PIN WW Domain

Songpon Deechongkit, Jeffery W. Kelly

Journal of the American Chemical Society > 2002 > 124 > 18 > 4980 - 4986

article

Anion Shielding of Electrostatic Repulsions in Transthyretin Modulates Stability and Amyloidosis: Insight into the Chaotrope Unfolding Dichotomy ^†

Per Hammarström, Xin Jiang, Songpon Deechongkit, Jeffery W. Kelly

Biochemistry > 2001 > 40 > 38 > 11453 - 11459

article

Solution structure of the third immunoglobulin domain of the neural cell adhesion molecule N-CAM: can solution studies define the mechanism of homophilic binding?

Annette R. Atkins, John Chung, SongPon Deechongkit, Edward B. Little, more

Journal of Molecular Biology > 2001 > 311 > 1 > 161-172

Homophilic binding of the neural cell adhesion molecule (N-CAM) mediates the calcium-independent cell-cell adhesion that is involved in neuronal development. Two hypotheses have been advanced for the mechanism of homophilic binding. Cell-based experiments have implicated each of the five extracellular immunoglobulin (Ig) domains of N-CAM in the homophilic adhesion interaction, and have predicted that...

article

An amino acid that controls polypeptide helicity: β-amino alanine, the first strongly stabilizing C-terminal helix stop signal

Songpon Deechongkit, Robert J. Kennedy, Kwok Yin Tsang, Peter Renold, more

Tetrahedron Letters > 2000 > 41 > 49 > 9679 - 9683

β-Amino alanine is shown to stop helix propagation in a polyalanine context while effectively stabilizing the resulting C-terminus. Structural evidence is provided by circular dichroism and t/c ratios from the reporting conformational template Ac-Hel.

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