Search results for: Maria Martínez-Yamout

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article

Overexpression of post-translationally modified peptides in Escherichia coli by co-expression with modifying enzymes

Kenji Sugase, Mindy A. Landes, Peter E. Wright, Maria Martinez-Yamout

Protein Expression and Purification > 2008 > 57 > 2 > 108-115

Post-translational modification plays crucial roles in signal transduction in eukaryotic cells. To elucidate the biological function of a protein with a specific post-translational modification, it is necessary to isolate the modified protein. However, it is difficult to incorporate a modified amino acid into a specific position of a protein, in particular, in a large-scale preparation. In order to...

article

The Zinc-dependent Redox Switch Domain of the Chaperone Hsp33 has a Novel Fold

Hyung-Sik Won, Lieh Yoon Low, Roberto De Guzman, Maria Martinez-Yamout, more

Journal of Molecular Biology > 2004 > 341 > 4 > 893-899

The Escherichia coli chaperone Hsp33 contains a C-terminal zinc-binding domain that modulates activity by a so-called “redox switch”. The oxidized form in the absence of zinc is active, while the reduced form in the presence of zinc is inactive. X-ray crystal structures of Hsp33 invariably omit details of the C-terminal domain, which is truncated in protein constructs that are capable of forming crystals...

article

Structure of the Nuclear Factor ALY: Insights into Post-Transcriptional Regulatory and mRNA Nuclear Export Processes ^†

Gabriela C. Pérez-Alvarado, Maria Martínez-Yamout, Melissa M. Allen, Rudolf Grosschedl, more

Biochemistry > 2003 > 42 > 24 > 7348 - 7357

article

Structure of the PHD Zinc Finger from Human Williams-Beuren Syndrome Transcription Factor

Jaime Pascual, Maria Martinez-Yamout, H.Jane Dyson, Peter E. Wright

Journal of Molecular Biology > 2000 > 304 > 5 > 723-729

The PHD (plant homeo domain) is a ∼50-residue motif found mainly in proteins involved in eukaryotic transcription regulation. The characteristic sequence feature is a conserved Cys ₄ -HisCys ₃ zinc binding motif. We have determined the solution structure of the PHD motif from the human Williams-Beuren syndrome transcription factor (WSTF) protein. The domain folds into an interleaved...

article

Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP

Roberto N. De Guzman, Hong Yu Liu, Maria Martinez-Yamout, H.Jane Dyson, more

Journal of Molecular Biology > 2000 > 303 > 2 > 243-253

The TAZ2 (CH3) domain of the transcriptional adapter protein CBP has been implicated in direct functional interactions with numerous cellular transcription factors and viral oncoproteins. The solution structure of the TAZ2 domain of murine CBP has been determined by nuclear magnetic resonance (NMR). The protein adopts a novel helical fold stabilized by three zinc ions, each of which is bound to one...

article

Solution Structure of the Cysteine-rich Domain of the Escherichia coli Chaperone Protein DnaJ

Maria Martinez-Yamout, Glen B. Legge, Ouwen Zhang, Peter E. Wright, more

Journal of Molecular Biology > 2000 > 300 > 4 > 805-818

The solution structure of the cysteine-rich (CR) domain of Escherichia coli DnaJ has been solved by NMR methods. The structure of a 79 residue CR domain construct shows a novel fold with an overall V-shaped extended β-hairpin topology. The CR domain is characterized by four C-X-X-C-X-G-X-G sequence motifs that bind two zinc ions. Residues in these two zinc modules show strong similarities in the grouping...

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DISTANCE GEOMETRY (2)
NMR (2)
NMR STRUCTURE (2)
SIMULATED ANNEALING (2)
B1 DOMAIN OF PROTEIN G (GB1) (1)
CHAPERONE DOMAIN (1)
CO-EXPRESSION (1)
CREB (1)
CYCLIC-AMP RESPONSE-ELEMENT BINDING PROTEIN (CBP) (1)
ESCHERICHIA COLI (1)
GENE SILENCING (1)
HIF-1Α (1)
HYDROXYLATION (1)
OXIDATION–REDUCTION (1)
OXIDATIVE STRESS (1)
PHOSPHORYLATION (1)
PROTEIN FOLDING (1)
TRANSCRIPTIONAL REGULATION (1)
ZINC-BINDING PROTEIN (1)
ZINC–CYSTEINE COORDINATION (1)
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Elsevier (5)
ACS (1)

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Search results for: Maria Martínez-Yamout

Overexpression of post-translationally modified peptides in Escherichia coli by co-expression with modifying enzymes

The Zinc-dependent Redox Switch Domain of the Chaperone Hsp33 has a Novel Fold

Structure of the Nuclear Factor ALY: Insights into Post-Transcriptional Regulatory and mRNA Nuclear Export Processes †

Structure of the PHD Zinc Finger from Human Williams-Beuren Syndrome Transcription Factor

Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP

Solution Structure of the Cysteine-rich Domain of the Escherichia coli Chaperone Protein DnaJ

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Structure of the Nuclear Factor ALY: Insights into Post-Transcriptional Regulatory and mRNA Nuclear Export Processes ^†