Search results for: Jens Peter Andersen

Items from 1 to 20 out of 23 results

article

The decrease in uncited articles and its effect on the concentration of citations

Diego Kozlowski, Jens Peter Andersen, Vincent Larivière

Journal of the Association for Information Science and Technology > 75 > 2 > 188 - 197

Empirical evidence demonstrates that citations received by scholarly publications follow a pattern of preferential attachment, resulting in a power‐law distribution. Such asymmetry has sparked significant debate regarding the use of citations for research evaluation. However, a consensus has yet to be established concerning the historical trends in citation concentration. Are citations becoming more...

article

Electrogenic reaction step and phospholipid translocation pathway of the mammalian P4‐ATPase ATP8A2

Francesco Tadini‐Buoninsegni, Stine A. Mikkelsen, Louise S. Mogensen, Rikke Holm, more

FEBS Letters > 597 > 4 > 495 - 503

ATP8A2 is a mammalian P4‐ATPase (flippase) that translocates the negatively charged lipid substrate phosphatidylserine from the exoplasmic leaflet to the cytoplasmic leaflet of cellular membranes. Using an electrophysiological method based on solid supported membranes, we investigated the electrogenicity of specific reaction steps of ATP8A2 and explored a potential phospholipid translocation pathway...

article

Google Scholar and Web of Science: Examining gender differences in citation coverage across five scientific disciplines

Jens Peter Andersen, Mathias Wullum Nielsen

Journal of Informetrics > 2018 > 12 > 3 > 950-959

Many studies demonstrate differences in the coverage of citing publications in Google Scholar (GS) and Web of Science (WoS). Here, we examine to what extent citation data from the two databases reflect the scholarly impact of women and men differently. Our conjecture is that WoS carries an indirect gender bias in its selection criteria for citation sources that GS avoids due to criteria that are more...

article

Mapping international impact of Danish neuroscience from 2004 to 2015 using tailored scientometric methodology

Jens Peter Andersen, Kim Krogsgaard, Anne‐Marie Engel, Jesper W. Schneider

European Journal of Neuroscience > 47 > 3 > 193 - 200

article

An empirical and theoretical critique of the Euclidean index

Jens Peter Andersen

Journal of Informetrics > 2017 > 11 > 2 > 455-465

The recently proposed Euclidean index offers a novel approach to measure the citation impact of academic authors, in particular as an alternative to the h-index. We test if the index provides new, robust information, not covered by existing bibliometric indicators, discuss the measurement scale and the degree of distinction between analytical units the index offers. We find that the Euclidean index...

article

Rescue of defective ATP8B1 trafficking by CFTR correctors as a therapeutic strategy for familial intrahepatic cholestasis

Wendy L. van der Woerd, Catharina G.K. Wichers, Anna L. Vestergaard, Jens Peter Andersen, more

Journal of Hepatology > 2016 > 64 > 6 > 1339-1347

ATP8B1 deficiency is an autosomal recessive liver disease characterized by intrahepatic cholestasis. ATP8B1 mutation p.I661T, the most frequent mutation in European patients, results in protein misfolding and impaired targeting to the plasma membrane. Similarly, mutations in cystic fibrosis transmembrane conductance regulator (CFTR), associated with cystic fibrosis, impair protein folding and trafficking...

article

Crystal Structure of the Vanadate-Inhibited Ca2+-ATPase

Johannes D. Clausen, Maike Bublitz, Bertrand Arnou, Claus Olesen, more

Structure > 2016 > 24 > 4 > 617-623

Vanadate is the hallmark inhibitor of the P-type ATPase family; however, structural details of its inhibitory mechanism have remained unresolved. We have determined the crystal structure of sarcoplasmic reticulum Ca²⁺-ATPase with bound vanadate in the absence of Ca²⁺. Vanadate is bound at the catalytic site as a planar VO₃⁻ in complex with water and Mg²⁺ in a dephosphorylation transition-state-like...

article

Specific mutations in mammalian P4-ATPase ATP8A2 catalytic subunit entail differential glycosylation of the accessory CDC50A subunit

Anna L. Vestergaard, Stine A. Mikkelsen, Jonathan A. Coleman, Robert S. Molday, more

FEBS Letters > 2015 > 589 > 24(PB) > 3908-3914

P4-ATPases, or flippases, translocate phospholipids between the two leaflets of eukaryotic biological membranes. They are essential to the physiologically crucial phospholipid asymmetry and involved in severe diseases, but their molecular structure and mechanism are still unresolved. Here, we show that in an extensive mutational alanine screening of the mammalian flippase ATP8A2 catalytic subunit,...

article

Specific mutations in mammalian P4‐ATPase ATP8A2 catalytic subunit entail differential glycosylation of the accessory CDC50A subunit

Anna L. Vestergaard, Stine A. Mikkelsen, Jonathan A. Coleman, Robert S. Molday, more

FEBS Letters > 589 > 24PartB > 3908 - 3914

P4‐ATPases, or flippases, translocate phospholipids between the two leaflets of eukaryotic biological membranes. They are essential to the physiologically crucial phospholipid asymmetry and involved in severe diseases, but their molecular structure and mechanism are still unresolved. Here, we show that in an extensive mutational alanine screening of the mammalian flippase ATP8A2 catalytic subunit,...

article

Structural mechanics and regulation of the Ca2+-ATPase

Maike Bublitz, Johannes D. Clausen, Anne-Marie Lund Winther, Cédric Montigny, more

BBA - Bioenergetics > 2014 > 1837 > Supplement > e106

article

Coarse‐Grained Simulations of Transitions in the E2‐to‐E1 Conformations for Ca ATPase (SERCA) Show Entropy–Enthalpy Compensation

Anu Nagarajan, Jens Peter Andersen, Thomas B. Woolf

Journal of Molecular Biology > 2012 > 422 > 4 > 575-593

SERCA is a membrane transport protein that has been extensively studied. There are a large number of highly resolved X-ray structures and several hundred mutations that have been characterized functionally. Despite this, the molecular details of the catalytic cycle, a cycle that includes large conformational changes, is not fully understood. In this computational study, we provide molecular dynamics...

article

The role of domain: Domain interactions versus domain: Water interactions in the coarse‐grained simulations of the E1P to E2P transitions in Ca‐ATPase (SERCA)

Anu Nagarajan, Jens Peter Andersen, Thomas B. Woolf

Proteins: Structure, Function, and Bioinformatics > 80 > 8 > 1929 - 1947

SERCA is an important model system for understanding the molecular details of conformational change in membrane transport systems. This reflects the large number of solved X‐ray structures and the equally large database of mutations that have been assayed. In this computational study, we provide a molecular dynamics description of the conformational changes during the E1P → E2P transitions. This set...

article

Price revisited: on the growth of dissertations in eight research fields

Jens Peter Andersen, Björn Hammarfelt

Scientometrics > 2011 > 88 > 2 > 371-383

This paper studies the production of dissertations in eight research fields in the natural sciences, the social sciences and the humanities. In using doctoral dissertations it builds on De Solla Prices seminal study which used PhD dissertations as one of several indicators of scientific growth (Price, Little science, big science, 1963). Data from the ProQuest: Dissertations and Theses database covering...

article

P-type ATPases as drug targets: Tools for medicine and science

Laure Yatime, Morten J. Buch-Pedersen, Maria Musgaard, J. Preben Morth, more

BBA - Bioenergetics > 2009 > 1787 > 4 > 207-220

P-type ATPases catalyze the selective active transport of ions like H ⁺ , Na ⁺ , K ⁺ , Ca ²⁺ , Zn ²⁺ , and Cu ²⁺ across diverse biological membrane systems. Many members of the P-type ATPase protein family, such as the Na ⁺ ,K ⁺ -, H ⁺ ,K ⁺ -, Ca ²⁺ -, and H ⁺ -ATPases, are involved in the development of...

article

Roles of transmembrane segment M1 of Na⁺,K⁺-ATPase and Ca²⁺-ATPase, the gatekeeper and the pivot

Anja Pernille Einholm, Jens Peter Andersen, Bente Vilsen

Journal of Bioenergetics and Biomembranes > 2007 > 39 > 5-6 > 357-366

In this review we summarize mutagenesis work on the structure–function relationship of transmembrane segment M1 in the Na⁺,K⁺-ATPase and the sarco(endo)plasmic reticulum Ca²⁺-ATPase. The original hypothesis that charged residues in the N-terminal part of M1 interact with the transported cations can be rejected. On the other hand hydrophobic residues in the middle part of M1 turned out to play crucial...

article

Roles of Leu249, Lys252, and Leu253 in Membrane Segment M3 of Sarcoplasmic Reticulum Ca ²⁺ -ATPase in Control of Ca ²⁺ Migration and Long-Range Intramolecular Communication ^†

Johannes D. Clausen, Jens Peter Andersen

Biochemistry > 2003 > 42 > 9 > 2585 - 2594

article

Site-directed mutagenesis studies of energy coupling in the sarcoplasmic reticulum Ca ² ⁺ -ATPase

Jens Peter Andersen, Thomas Sørensen

BBA - Bioenergetics > 1996 > 1275 > 1-2 > 118-122

Site-directed mutagenesis studies identifying residues important to energy transduction in the sarcoplasmic reticulum Ca ² ⁺ -ATPase are reviewed. Mutations blocking the crucial E1P to E2P transition are located in the small and the large cytoplasmic domains, in the stalk segment S4 linking transmembrane segment M4 with the catalytic site, as well as in transmembrane segments M4 and M8...

article

Structure-function relationships of cation translocation by Ca ² ⁺ - and Na ⁺ ,K ⁺ -ATPases studied by site-directed mutagenesis

Jens Peter Andersen, Bente Vilsen

FEBS Letters > 1995 > 359 > 2-3 > 101-106

Site-directed mutagenesis studies of the sarcoplasmic reticulum Ca ² ⁺ -ATPase have pinpointed five amino acid residues that are essential to Ca ² ⁺ occlusion, and these residues have been assigned to different parts of a Ca ² ⁺ binding pocket with channel-like structure. Three of the homologous Na ⁺ ,K ⁺ -ATPase residues have been shown to be important...

article

Mutational analysis of Glu ⁷ ⁷ ¹ of the Ca ² ⁺ -ATPase of sarcoplasmic reticulum Effect of positive charge on dephosphorylation

Jens Peter Andersen

FEBS Letters > 1994 > 354 > 1 > 93-96

The glutamic acid residue Glu ⁷ ⁷ ¹ in the fifth transmembrane segment M5 of the Ca ² ⁺ -ATPase of rabbit fast twitch muscle sarcoplasmic reticulum was substituted with lysine, alanine, and glycine by site-directed mutagenesis. Mutant Glu ⁷ ⁷ ¹ ->Lys was unable to occlude Ca ² ⁺ , and Ca ² ⁺ did not inhibit phosphorylation from...

article

New comprehensive biochemistry, vol. 25: Protein-lipid interactions - edited by A. Watts, Elsevier Science B.V., Amsterdam, 1993; xviii + 379 pages. ISBN 0-444-81575-9, 0-444-80303-3 (series).

Jens Peter Andersen

FEBS Letters > 1994 > 352 > 3 > 400

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INFONA - science communication portal

Search results for: Jens Peter Andersen

The decrease in uncited articles and its effect on the concentration of citations

Electrogenic reaction step and phospholipid translocation pathway of the mammalian P4‐ATPase ATP8A2

Google Scholar and Web of Science: Examining gender differences in citation coverage across five scientific disciplines

Mapping international impact of Danish neuroscience from 2004 to 2015 using tailored scientometric methodology

An empirical and theoretical critique of the Euclidean index

Rescue of defective ATP8B1 trafficking by CFTR correctors as a therapeutic strategy for familial intrahepatic cholestasis

Crystal Structure of the Vanadate-Inhibited Ca2+-ATPase

Specific mutations in mammalian P4-ATPase ATP8A2 catalytic subunit entail differential glycosylation of the accessory CDC50A subunit

Specific mutations in mammalian P4‐ATPase ATP8A2 catalytic subunit entail differential glycosylation of the accessory CDC50A subunit

Structural mechanics and regulation of the Ca2+-ATPase

Coarse‐Grained Simulations of Transitions in the E2‐to‐E1 Conformations for Ca ATPase (SERCA) Show Entropy–Enthalpy Compensation

The role of domain: Domain interactions versus domain: Water interactions in the coarse‐grained simulations of the E1P to E2P transitions in Ca‐ATPase (SERCA)

Price revisited: on the growth of dissertations in eight research fields

P-type ATPases as drug targets: Tools for medicine and science

Roles of transmembrane segment M1 of Na⁺,K⁺-ATPase and Ca²⁺-ATPase, the gatekeeper and the pivot

Roles of Leu249, Lys252, and Leu253 in Membrane Segment M3 of Sarcoplasmic Reticulum Ca ²⁺ -ATPase in Control of Ca ²⁺ Migration and Long-Range Intramolecular Communication ^†

Site-directed mutagenesis studies of energy coupling in the sarcoplasmic reticulum Ca ² ⁺ -ATPase

Structure-function relationships of cation translocation by Ca ² ⁺ - and Na ⁺ ,K ⁺ -ATPases studied by site-directed mutagenesis

Mutational analysis of Glu ⁷ ⁷ ¹ of the Ca ² ⁺ -ATPase of sarcoplasmic reticulum Effect of positive charge on dephosphorylation

New comprehensive biochemistry, vol. 25: Protein-lipid interactions - edited by A. Watts, Elsevier Science B.V., Amsterdam, 1993; xviii + 379 pages. ISBN 0-444-81575-9, 0-444-80303-3 (series).

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