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The crystal structure of the human class III χχ alcohol dehydrogenase (ADH) in a binary complex with NAD +γ was solved to 2.7 A resolution by molecular replacement with human class I β 1 β 1 ADH. χχ ADH catalyzes the oxidation of long-chain alcohols such as ω-hydroxy fatty acids as well as S-hydroxymethyl-glutathione, a spontaneous adduct between formal dehyde and...
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