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Jak3 is a protein tyrosine kinase that is associated with the shared γ chain of receptors for cytokines IL2, IL4, IL7, IL9, and IL13. We have discovered that a pyridone-containing tetracycle (6) may be prepared from trisubstituted imidazole (5) in high yield by irradiation with >350 nm light. Compound 6 inhibits Jak3 with KI=5 nM; it also inhibits Jak family members Tyk2 and Jak2 with IC50=1 nM...
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