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The chemistry of RNA degradation by Fe bleomycin was studied using two RNA substrates that are modified efficiently at a small number of sites by the antitumor antibiotic. Cleavage of a tRNA His precursor transcript by Fe(II) BLM A 2 was shown to require O 2 ; cleavage was also observed when the same substrate was treated with Fe(III) BLM A 2 + H 2...
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