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An alumina (Al2O3)–steroid–ethanol model is used for forced degradation testing of corticosteroids to predict chemical stability and degradation products in pressurized metered‐dose inhaler (pMDI) solution formulations. The model involves an ethanolic solution of a test steroid with Al2O3, stressed at elevated temperatures to mimic the chemical interaction of drug, excipient, and packaging (an aluminum...
The translation initiation factor eIF1A is necessary for directing the 43S preinitiation complex from the 5' end of the mRNA to the initiation codon in a process termed scanning. We have determined the solution structure of human eIF1A, which reveals an oligonucleotide-binding (OB) fold and an additional domain. NM R titration experiments showed that eIF1A binds single-stranded RNA oligonucleotides...
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