Search results for: Rikard Owenius

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CEREBROSPINAL FLUID Aβ42 ANALYZED AS PART OF CLINICAL ROUTINE CAN ACCURATELY DISTINGUISH AMYLOID-POSITIVE FROM AMYLOID-NEGATIVE INDIVIDUALS

Oskar Hansson, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, more

Alzheimer's & Dementia: The Journal of the Alzheimer's Association > 2014 > 10 > 4 Supplement > P219-P220

article

[¹⁸F]Fluciclatide in the in vivo evaluation of human melanoma and renal tumors expressing α_vβ₃ and α_vβ₅ integrins

Esther Mena, Rikard Owenius, Baris Turkbey, Richard Sherry, more

European Journal of Nuclear Medicine and Molecular Imaging > 2014 > 41 > 10 > 1879-1888

Purpose [¹⁸F]Fluciclatide is an integrin-targeted PET radiopharmaceutical. α_vβ₃ and α_vβ₅ are upregulated in tumor angiogenesis as well as on some tumor cell surfaces. Our aim was to use [¹⁸F]fluciclatide (formerly known as [¹⁸F]AH111585) for PET imaging of angiogenesis in melanoma and renal tumors and compare with tumor integrin expression. Methods Eighteen evaluable patients with solid tumors ≥2...

article

Regional distribution and kinetics of [¹⁸F]fluciclovine (anti-[¹⁸F]FACBC), a tracer of amino acid transport, in subjects with primary prostate cancer

Jens Sörensen, Rikard Owenius, Michelle Lax, Silvia Johansson

European Journal of Nuclear Medicine and Molecular Imaging > 2013 > 40 > 3 > 394-402

Purpose [¹⁸F]Fluciclovine (anti-[¹⁸F]FACBC) is a synthetic amino acid developed for PET assessment of the anabolic component of tumour metabolism in clinical routine. This phase 1 trial evaluated the safety, tracer stability and uptake kinetics of [¹⁸F]fluciclovine in patients. Methods Six patients with biopsy-proven prostate cancer were investigated with 3-T MRI and PET/CT. All underwent dynamic...

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Gaussian Process Models of Dynamic PET for Functional Volume Definition in Radiation Oncology

Tony Shepherd, Rikard Owenius

IEEE Transactions on Medical Imaging > 2012 > 31 > 8 > 1542 - 1556

In routine oncologic positron emission tomography (PET), dynamic information is discarded by time-averaging the signal to produce static images of the “standardised uptake value” (SUV). Defining functional volumes of interest (VOIs) in terms of SUV is flawed, as values are affected by confounding factors and the chosen time window, and SUV images are not sensitive to functional heterogeneity of pathological...

article

¹⁸F‐flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial

Rik Vandenberghe, Koen Van Laere, Adrian Ivanoiu, Eric Salmon, more

Annals of Neurology > 68 > 3 > 319 - 329

ObjectiveThe most widely studied positron emission tomography ligand for in vivo β‐amyloid imaging is ¹¹C‐Pittsburgh compound B (¹¹C‐PIB). Its availability, however, is limited by the need for an on‐site cyclotron. Validation of the ¹⁸F‐labeled PIB derivative ¹⁸F‐flutemetamol could significantly enhance access to this novel technology. MethodsTwenty‐seven patients with early‐stage clinically probable...

article

Pons as an alternative reference region in [18F]flutemetamol quantification of amyloidosis

Kerstin Heurling, Rik Vandenberghe, Rikard Owenius, Lennart Thurfjell, more

NeuroImage > 2010 > 52 > Supplement 1 > S137

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Subject classification from [18F]flutemetamol data into categories of raised or low levels of beta-amyloid: Concordance between quantitative and visual assessment

Rikard Owenius, Lennart Thurfjell, Chris J. Buckley, Rik Vandenberghe, more

NeuroImage > 2010 > 52 > Supplement 1 > S144

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Concordance between visual read and quantification for categorisation of [18F]Flutemetamol data into either normal or abnormal amyloid levels

Lennart Thurfjell, Chris J. Buckley, Rikard Owenius, Gill Farrar, more

Alzheimer's & Dementia > 2010 > 6 > 4(S) > S71-S72

article

GroEL-induced topological dislocation of a substrate protein β-sheet core: a solution EPR spin–spin distance study

Rikard Owenius, Anngelica Jarl, Bengt-Harald Jonsson, Uno Carlsson, more

Journal of Chemical Biology > 2010 > 3 > 3 > 127-139

The Hsp60-type chaperonin GroEL assists in the folding of the enzyme human carbonic anhydrase II (HCA II) and protects it from aggregation. This study was aimed to monitor conformational rearrangement of the substrate protein during the initial GroEL capture (in the absence of ATP) of the thermally unfolded HCA II molten-globule. Single- and double-cysteine mutants were specifically spin-labeled at...

article

P1-303: Phase I study of the 18F-labelled benzothiazole derivative [18F]AH110690 as a biomarker of Alzheimer's disease–related brain amyloidosis

Rik Vandenberghe, Lennart Thurfjell, Rikard Owenius, David J. Brooks, more

Alzheimer's & Dementia: The Journal of the Alzheimer's Association > 2008 > 4 > 4 Supplement > T308

article

Frequency (250MHz to 9.2GHz) and viscosity dependence of electron spin relaxation of triarylmethyl radicals at room temperature

Rikard Owenius, Gareth R. Eaton, Sandra S. Eaton

Journal of Magnetic Resonance > 2005 > 172 > 1 > 168-175

Electron spin relaxation times for four triarylmethyl (trityl) radicals at room temperature were measured by long-pulse saturation recovery, inversion recovery, and electron spin echo at 250MHz, 1.5, 3.1, and 9.2GHz in mixtures of water and glycerol. At 250MHz T ₁ is shorter than at X-band and more strongly dependent on viscosity. The enhanced relaxation at 250MHz is attributed to modulation...

article

Frequency Dependence of Electron Spin Relaxation of Nitroxyl Radicals in Fluid Solution ^†

Rikard Owenius, Garth E. Terry, Mitchell J. Williams, Sandra S. Eaton, more

The Journal of Physical Chemistry B > 2004 > 108 > 27 > 9475 - 9481

article

Influence of Solvent Polarity and Hydrogen Bonding on the EPR Parameters of a Nitroxide Spin Label Studied by 9-GHz and 95-GHz EPR Spectroscopy and DFT Calculations

Rikard Owenius, Maria Engström, Mikael Lindgren, Martina Huber

The Journal of Physical Chemistry A > 2001 > 105 > 49 > 10967 - 10977

article

Spin and Fluorescent Probing of the Binding Interface between Tissue Factor and Factor VIIa at Multiple Sites

Rikard Owenius, Maria Österlund, Magdalena Svensson, Mikael Lindgren, more

Biophysical Journal > 2001 > 81 > 4 > 2357-2369

The specific complex between the extracellular part of tissue factor (sTF) and factor VIIa (FVIIa) was chosen as a model for studies of the binding interface between two interacting proteins. Six surface-exposed positions in sTF, residues known to contribute to the sTF-FVIIa interaction, were selected for cysteine mutation and site-directed labeling with spin and fluorescent probes. The binding interface...

article

Probing Inhibitor-Induced Conformational Changes along the Interface between Tissue Factor and Factor VIIa

Maria Österlund, Rikard Owenius, Karin Carlsson, Uno Carlsson, more

Biochemistry > 2001 > 40 > 31 > 9324 - 9328

article

High-Resolution Probing of Local Conformational Changes in Proteins by the Use of Multiple Labeling: Unfolding and Self-Assembly of Human Carbonic Anhydrase II Monitored by Spin, Fluorescent, and Chemical Reactivity Probes

Per Hammarström, Rikard Owenius, Lars-Göran Mårtensson, Uno Carlsson, more

Biophysical Journal > 2001 > 80 > 6 > 2867-2885

Two different spin labels, N-(1-oxyl-2,2,5,5-tetramethyl-3-pyrrolidinyl)iodoacetamide (IPSL) and (1-oxyl-2,2,5,5-tetramethylpyrroline-3-methyl) methanethiosulfonate (MTSSL), and two different fluorescent labels 5-((((2-iodoacetyl)amino)-ethyl)amino)naphtalene-1-sulfonic acid (IAEDANS) and 6-bromoacetyl-2-dimetylaminonaphtalene (BADAN), were attached to the introduced C79 in human carbonic anhydrase...

article

Ab initio g-tensor calculations of hydrogen bond effects on a nitroxide spin label

Maria Engström, Rikard Owenius, Olav Vahtras

Chemical Physics Letters > 2001 > 338 > 4-6 > 407-413

Hydrogen bonding effects on the electron paramagnetic resonance (EPR) g-tensor of a nitroxide spin label was investigated by quantum chemical calculations. The restricted open-shell Hartree-Fock (ROHF) linear response method with the atomic mean field approximation (AMFI) was used in the calculations. The results show that hydrogen bonding reduces the g-tensor component directed along the NO bond,...

article

Properties of Spin and Fluorescent Labels at a Receptor-Ligand Interface

Rikard Owenius, Maria Österlund, Mikael Lindgren, Magdalena Svensson, more

Biophysical Journal > 1999 > 77 > 4 > 2237-2250

Site-directed labeling was used to obtain local information on the binding interface in a receptor-ligand complex. As a model we have chosen the specific association of the extracellular part of tissue factor (sTF) and factor VIIa (FVIIa), the primary initiator of the blood coagulation cascade. Different spectroscopic labels were covalently attached to an engineered cysteine in position 140 in sTF,...

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