Search results for: Kazuko Handa

Items from 1 to 20 out of 24 results

article

Retraction: Human monoclonal antibody GNX‐8 directed to extended type 1 chain: specific binding to human colorectal cancer

Mei‐Chun Yang, Feng‐Lin Hsu, Kazuko Handa, Senitiroh Hakomori, more

International Journal of Cancer > 141 > 8 > 1711 - 1711

The above article, published online on 21 December 2009 in Wiley Online Library (wileyonlinelibrary.com), has been withdrawn by agreement between the journal Editor in Chief, Prof. Peter Lichter, and John Wiley & Sons Ltd. The withdrawal has been agreed due to the authors having requested that the paper not be officially published until a patent issue had been resolved. Although many attempts...

article

Functional role of glycosphingolipids in contact inhibition of growth in a human mammary epithelial cell line

Xiaohua Huang, Nathan Schurman, Kazuko Handa, Senitiroh Hakomori

FEBS Letters > 591 > 13 > 1918 - 1928

We have demonstrated previously the involvement of certain glycosphingolipids (GSLs) in ‘contact inhibition’ (dependent on cell‐to‐cell contact) of cell growth. Here, we examined the roles of specific GSLs in contact inhibition of the human epithelial cell line MCF10A. Contact‐inhibited cells show increased expression of the ganglioside GD3 and the globo‐series GSL Gb3, and of the mRNAs for the corresponding...

article

Changes of glycoconjugate expression profiles during early development

Kazuko Handa, Sen-itiroh Hakomori

Glycoconjugate Journal > 2017 > 34 > 6 > 693-699

A variety of glycoconjugates, including glycosphingolipids (GSLs), expressed in mammalian tissues and cells were isolated and characterized in early biochemical studies. Later studies of virus-transformed fibroblasts demonstrated the association of GSL expression profiles with cell phenotypes. Changes of GSL expression profile were observed during mammalian embryogenesis. Cell surface molecules expressed...

article

GM3 and cancer

Sen-Itiroh Hakomori, Kazuko Handa

Glycoconjugate Journal > 2015 > 32 > 1-2 > 1-8

Our studies during the early 1970s showed that expression of GM3, the simplest ganglioside and an abundant animal cell membrane component, is reduced during malignant transformation of cells by oncogenic viruses. Levels of mRNA for GM3 synthase were reduced in avian and mammalian cells transformed by oncoprotein “v-Jun”, and overexpression of GM3 synthase in the transformed cells caused reversion...

article

Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin

Yao Ding, Kirill Gelfenbeyn, Leonardo Freire-de-Lima, Kazuko Handa, more

FEBS Letters > 2012 > 586 > 13 > 1813-1820

Epithelial-mesenchymal transition (EMT) has been shown to play a key role in embryogenesis and cancer progression. We previously found that fibronectin (FN) carrying O-GalNAc at a specific site is selectively expressed in cancer and fetal cells/tissues, and termed oncofetal FN (onfFN). Here, we show that (i) a newly-established monoclonal antibody against FN lacking the O-GalNAc, termed normalFN (norFN),...

article

Carbohydrate to carbohydrate interaction in development process and cancer progression

Kazuko Handa, Sen-itiroh Hakomori

Glycoconjugate Journal > 2012 > 29 > 8-9 > 627-637

Two types of carbohydrate to carbohydrate interaction (CCI) have been known to be involved in biological processes. One is the CCI between molecules expressed on interfacing cell membranes of different cells to mediate cell to cell adhesion, and subsequently induce cell signaling, and is termed trans-CCI. It has been indicated that the Le^x to Le^x interaction at the morula stage in mouse embryos plays...

article

Erratum to: Carbohydrate to carbohydrate interaction in development process and cancer progression

Kazuko Handa, Sen-itiroh Hakomori

Glycoconjugate Journal > 2012 > 29 > 8-9 > 639-639

article

Regulation of Epidermal Growth Factor Receptor Through Interaction of Ganglioside GM3 with GlcNAc of N-Linked Glycan of the Receptor: Demonstration in ldlD Cells

Feng Guan, Kazuko Handa, Sen-itiroh Hakomori

Neurochemical Research > 2011 > 36 > 9 > 1645-1653

We investigated interaction of GM3 with N-acetylglucosamine (GlcNAc) termini of N-linked glycans of epidermal growth factor receptor (EGFR), as the underlying mechanism for inhibitory effect of GM3 on EGFR activation, using ldlD cells transfected with EGFR gene. These cells, defective in UDP-Gal/UDP-GalNAc 4-epimerase, are incapable of synthesizing galactose (Gal)-containing glycans, unless Gal is...

article

Lex glycan mediates homotypic adhesion of embryonal cells independently from E-cadherin: A preliminary note

Kazuko Handa, Tomoka Takatani-Nakase, Lionel Larue, Marc P. Stemmler, more

Biochemical and Biophysical Research Communications > 2007 > 358 > 1 > 247-252

Le ^x glycan and E-cadherin (Ecad) are co-expressed at embryonal stem (ES) cells and embryonal carcinoma (EC) cells. While the structure and function of Ecad mediating homotypic adhesion of these cells have been well established, evidence that Le ^x glycan also mediates such adhesion is weak, despite the fact that Le ^x oligosaccharide inhibits the compaction process. To provide...

article

A sphingosine-dependent protein kinase that specifically phosphorylates 14-3-3 (SDK1) is identified as the kinase domain of PKCδ: a preliminary note

Akikazu Hamaguchi, Erika Suzuki, Kimie Murayama, Tsutomu Fujimura, more

Biochemical and Biophysical Research Communications > 2003 > 307 > 3 > 589-594

A specific protein kinase that phosphorylates Ser60, Ser59, or Ser58 of 14-3-3β, η, or ζ, respectively, only in the presence of sphingosine (Sph) or N,N-dimethyl-Sph (DMS), was termed ''sphingosine-dependent protein kinase-1'' (SDK1) [J. Biol. Chem. 273(34) (1998) 21834]. We have now identified SDK1 as a protein having the same amino acid sequence as in the C-terminal-half kinase domain of PKCδ, with...

article

Monosialyl-Gb5 organized with cSrc and FAK in GEM of human breast carcinoma MCF-7 cells defines their invasive properties

Wim F Steelant, Yasushi Kawakami, Akihiro Ito, Kazuko Handa, more

FEBS Letters > 2002 > 531 > 1 > 93-98

Two human mammary carcinoma cell variants, MCF-7/AZ and MCF-7/6, show the same composition in their glycosphingolipid-enriched microdomain (GEM) with regard to globo-series structures Gb3, Gb4, Gb5, monosialyl-Gb5, GM2, and cSrc and FAK. Both variants are non-invasive into collagen gel layer, and showed similar motility in wound migration assay. Whereas invasiveness and motility of MCF-7/AZ cells...

article

Glycosphingolipid-dependent cross-talk between glycosynapses interfacing tumor cells with their host cells: essential basis to define tumor malignancy

Senitiroh Hakomori, Kazuko Handa

FEBS Letters > 2002 > 531 > 1 > 88-92

Status of tumor progression (either remaining in situ, or becoming invasive/metastatic) may be defined largely by subtle interactions ('cross-talk') in a microenvironment formed by interfacing tumor cell and host cell membrane domains (termed 'glycosynapses') involved in glycosylation-dependent cell adhesion and signaling. Functional roles of tumor-associated gangliosides, organized in glycosynapses...

article

Volume 285, Number 3 (2001), pages 788–794

Kazuko Handa, Fred Jacobs, B.Michael Longenecker, Sen-itiroh Hakomori

Biochemical and Biophysical Research Communications > 2001 > 286 > 4 > 839

article

Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression

Akihiro Ito, Kazuko Handa, Donald A. Withers, Makoto Satoh, more

FEBS Letters > 2001 > 504 > 1-2 > 82-86

Previous studies indicate that expression of higher gangliosides in renal cell carcinoma (RCC) is correlated with metastatic potential, particularly in the lung. Out of five major gangliosides in RCC, three disialogangliosides (disialogalactosylgloboside, IV³NeuAcIII⁶NeuAcLc₄, and IV⁴GalNAcIV³NeuAcIII⁶NeuAcLc₄) bind strongly to siglec7, which is expressed highly in monocytes and natural killer cells...

article

Erratum to: Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression (FEBS 24901)

Akihiro Ito, Kazuko Handa, Donald A. Withers, Makoto Satoh, more

FEBS Letters > 2001 > 504 > 1-2 > 81

article

Association of MUC-1 and PSGL-1 with Low-Density Microdomain in T-Lymphocytes: A Preliminary Note

Kazuko Handa, Fred Jacobs, B. Michael Longenecker, Sen-itiroh Hakomori

Biochemical and Biophysical Research Communications > 2001 > 285 > 3 > 788-794

Two mucin-type glycoproteins, MUC-1 and P-selectin glycoprotein ligand-1 (PSGL-1), and glycosphingolipids (GSLs), expressed in human T-cell line HUT78, were highly enriched in low-density buoyant fraction (termed ''GEM''), together with CD45, Yes, Fyn, and lck ⁵ ⁶ . Enrichment of MUC-1, PSGL-1 and GSLs, together with these signal transducer molecules in low-density membrane fraction was...

article

Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression

Akihiro Ito, Kazuko Handa, Donald A. Withers, Makoto Satoh, more

FEBS Letters > 2001 > 498 > 1 > 116-120

Previous studies indicate that expression of higher gangliosides in renal cell carcinoma (RCC) is correlated with metastatic potential, particularly in the lung. Out of five major gangliosides in RCC, three disialogangliosides (disialogalactosylgloboside, IV ³ NeuAcIII ⁶ NeuAcLc ₄ , and IV ⁴ GalNAcIV ³ NeuAcIII ⁶ NeuAcLc ₄ ) bind strongly to...

article

GM3 Ganglioside Inhibits CD9-Facilitated Haptotactic Cell Motility: Coexpression of GM3 and CD9 Is Essential in the Downregulation of Tumor Cell Motility and Malignancy ^†

Masaya Ono, Kazuko Handa, Sandro Sonnino, Donald A. Withers, more

Biochemistry > 2001 > 40 > 21 > 6414 - 6421

article

Glycosylation Effect on Membrane Domain (GEM) Involved in Cell Adhesion and Motility: A Preliminary Note on Functional α3, α5-CD82 Glycosylation Complex in ldlD 14 Cells

Masaya Ono, Kazuko Handa, Donald A. Withers, Sen-itiroh Hakomori

Biochemical and Biophysical Research Communications > 2000 > 279 > 3 > 744-750

Laminin (LN)- or fibronectin (FN)-dependent adhesion in Krieger's ldlD 14 (D14) cells is enhanced significantly in the presence vs absence, of galactose (Gal), whereas LN- or FN-induced haptotactic cell motility is barely affected unless cells express CD82 by its gene transfection (cells termed D14/CD82). The effect of CD82 on LN- or FN-induced motility is based on its ability to associate with α3...

article

Glycosylation Affects Translocation of Integrin, Src, and Caveolin into or out of GEM

Akira Kazui, Masaya Ono, Kazuko Handa, Sen-itiroh Hakomori

Biochemical and Biophysical Research Communications > 2000 > 273 > 1 > 159-163

Endogenous GM3 synthesis and full N-glycosylation in membrane receptors occurred in “4-epimerase-less” ldlD (Krieger's CHO mutant) cells cultured in Gal-containing medium, whereby components of detergent-insoluble, low-density, buoyant membrane fraction, termed “glycolipid-enriched microdomain (GEM),” varied significantly by translocation into or out of GEM. Integrins α3 and α5 were translocated into...

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Search results for: Kazuko Handa

Retraction: Human monoclonal antibody GNX‐8 directed to extended type 1 chain: specific binding to human colorectal cancer

Functional role of glycosphingolipids in contact inhibition of growth in a human mammary epithelial cell line

Changes of glycoconjugate expression profiles during early development

GM3 and cancer

Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin

Carbohydrate to carbohydrate interaction in development process and cancer progression

Erratum to: Carbohydrate to carbohydrate interaction in development process and cancer progression

Regulation of Epidermal Growth Factor Receptor Through Interaction of Ganglioside GM3 with GlcNAc of N-Linked Glycan of the Receptor: Demonstration in ldlD Cells

Lex glycan mediates homotypic adhesion of embryonal cells independently from E-cadherin: A preliminary note

A sphingosine-dependent protein kinase that specifically phosphorylates 14-3-3 (SDK1) is identified as the kinase domain of PKCδ: a preliminary note

Monosialyl-Gb5 organized with cSrc and FAK in GEM of human breast carcinoma MCF-7 cells defines their invasive properties

Glycosphingolipid-dependent cross-talk between glycosynapses interfacing tumor cells with their host cells: essential basis to define tumor malignancy

Volume 285, Number 3 (2001), pages 788–794

Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression

Erratum to: Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression (FEBS 24901)

Association of MUC-1 and PSGL-1 with Low-Density Microdomain in T-Lymphocytes: A Preliminary Note

Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression

GM3 Ganglioside Inhibits CD9-Facilitated Haptotactic Cell Motility: Coexpression of GM3 and CD9 Is Essential in the Downregulation of Tumor Cell Motility and Malignancy ^†

Glycosylation Effect on Membrane Domain (GEM) Involved in Cell Adhesion and Motility: A Preliminary Note on Functional α3, α5-CD82 Glycosylation Complex in ldlD 14 Cells

Glycosylation Affects Translocation of Integrin, Src, and Caveolin into or out of GEM

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