Search results for: Valentina Rapozzi

Items from 1 to 15 out of 15 results

article

Critical role of hnRNP A1 in activating KRAS transcription in pancreatic cancer cells: A molecular mechanism involving G4 DNA

Susanna Cogoi, Valentina Rapozzi, Sabina Cauci, Luigi E. Xodo

Biochimica et Biophysica Acta (BBA) - General Subjects > 2017 > 1861 > 5(PB) > 1389-1398

KRAS is one of the most mutated genes in human cancer. Its crucial role in the tumourigenesis of pancreatic ductal adenocarcinoma (PDAC) has been widely demonstrated. As this deadly cancer does not sufficiently respond to conventional chemotherapies, it is important to increase our knowledge of pancreatic cancer biology, in particular how oncogenic KRAS is regulated. The promoter of KRAS contains...

article

A photodynamic bifunctional conjugate for prostate cancer: an in vitro mechanistic study

Valentina Rapozzi, Greta Varchi, Emilia Della Pietra, Claudia Ferroni, more

Investigational New Drugs > 2017 > 35 > 1 > 115-123

Summary Photodynamic therapy (PDT) has drawn considerable attention for its efficacy against certain types of cancers. It shows however limits in the case of deep cancers, favoring tumor recurrence under suboptimal conditions. More insight into the molecular mechanisms of PDT-induced cytotoxicity and cytoprotection is essential to extend and strengthen this therapeutic modality. As PDT induces iNOS/NO...

article

Repeated sub-optimal photodynamic treatments with pheophorbide a induce an epithelial mesenchymal transition in prostate cancer cells via nitric oxide

Emilia Della Pietra, Francesca Simonella, Benjamin Bonavida, Luigi Emilio Xodo, more

Nitric Oxide > 2015 > 45 > Complete > 43-53

Photodynamic therapy (PDT) is a clinically approved treatment that causes a selective cytotoxic effect in cancer cells. In addition to the production of singlet oxygen and reactive oxygen species, PDT can induce the release of nitric oxide (NO) by up-regulating nitric oxide synthases (NOS). Since non-optimal PDT often causes tumor recurrence, understanding the molecular pathways involved in the photoprocess...

article

Nitric oxide-mediated activity in anti-cancer photodynamic therapy

Valentina Rapozzi, Emilia Della Pietra, Sonia Zorzet, Marina Zacchigna, more

Nitric Oxide > 2013 > 30 > Complete > 26-35

Cell recurrence in cancer photodynamic therapy (PDT) is an important issue that is poorly understood. It is becoming clear that nitric oxide (NO) is a modulator of PDT. By acting on the NF-κB/Snail/RKIP survival/anti-apoptotic loop, NO can either stimulate or inhibit apoptosis. We found that pheophorbide a/PDT (Pba/PDT) induces the release of NO in B78-H1 murine amelanotic melanoma cells in a concentration-dependent...

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The PDT activity of free and pegylated pheophorbide a against an amelanotic melanoma transplanted in C57/BL6 mice

Valentina Rapozzi, Sonia Zorzet, Marina Zacchigna, Sara Drioli, more

Investigational New Drugs > 2013 > 31 > 1 > 192-199

Summary Pheophorbide a (Pba) is a chlorophyll catabolite that has been proposed as photosensitizer in photodynamic therapy. In a previous study we conjugated Pba to monomethoxy-polyethylene glycol (mPEG-Pba), to increase its solubility and pharmacokinetics. Here, we compare the photodynamic therapy efficacy of free Pba and mPEG-Pba to cure a subcutaneous amelanotic melanoma transplanted in C57/BL6...

article

Role of NF‐κB/Snail/RKIP loop in the response of tumor cells to photodynamic therapy

Valentina Rapozzi, Kazuo Umezawa, Luigi E. Xodo

Lasers in Surgery and Medicine > 43 > 7 > 575 - 585

Background and ObjectivePhotodynamic therapy (PDT) is a therapeutic modality whose efficacy depends on several factors including type of photosensitizer, light fluence and cellular response. Cell recurrence is one of the problems still unsolved in PDT. In this work we found that in B78‐H1 murine amelanotic melanoma cells there is a correlation between cell recurrence and the NF‐κB/Snail/RKIP loop...

article

Metallation of pentaphyrin with Lu(III) dramatically increases reactive-oxygen species production and cell phototoxicity

Maurizio Ballico, Valentina Rapozzi, Luigi E. Xodo, Clara Comuzzi

European Journal of Medicinal Chemistry > 2011 > 46 > 2 > 712-720

Photodynamic therapy (PDT) is an emerging cancer treatment modality based on the excitation of a nontoxic photosensitizer with harmless visible light to produce reactive-oxygen species (ROS) that induce apoptosis and/or necrosis in cancer cells. As the efficacy of this therapy strongly depends of the nature of the photosensitizer, there is a great interest to develop new photoactive molecules. Here...

article

Photooxidation and Phototoxicity of π-Extended Squaraines

Valentina Rapozzi, Luca Beverina, Patrizio Salice, Giorgio A. Pagani, more

Journal of Medicinal Chemistry > 2010 > 53 > 5 > 2188 - 2196

article

Efficient Silencing of bcr / abl Oncogene by Single- and Double-Stranded siRNAs Targeted against b2a2 Transcripts ^†

Valentina Rapozzi, Luigi Emilio Xodo

Biochemistry > 2004 > 43 > 51 > 16134 - 16141

article

Seasonal Dependency of the Effects of Rotational Stress and Cyclophosphamide in Mice Bearing Lewis Lung Carcinoma

Sonia Zorzet, Laura Perissin, Valentina Rapozzi, Tullio Giraldi

Brain Behavior and Immunity > 2002 > 16 > 4 > 368-382

The antitumor effects of cyclophosphamide were previously shown to be markedly reduced by the application of restraint stress in mice bearing Lewis lung carcinoma. The aim of this work was to determine the effects of rotational stress on the antitumor action of cyclophosphamide in the same animal–tumor system. Since the effects of rotational stress on metastasis were found to display a circannual...

article

Antigene Effect in K562 Cells of a PEG-Conjugated Triplex-Forming Oligonucleotide Targeted to the bcr / abl Oncogene ^†

Valentina Rapozzi, Susanna Cogoi, Paola Spessotto, Angela Risso, more

Biochemistry > 2002 > 41 > 2 > 502 - 510

article

Anti-gene Effect in Live Cells of AG Motif Triplex-Forming Oligonucleotides Containing an Increasing Number of Phosphorothioate Linkages ^†

Susanna Cogoi, Valentina Rapozzi, Franco Quadrifoglio, Luigi Xodo

Biochemistry > 2001 > 40 > 5 > 1135 - 1143

article

Melatonin decreases bone marrow and lymphatic toxicity of adriamycin in mice bearing TLX5 lymphoma

Valentina Rapozzi, Sonia Zorzet, Marina Comelli, Irene Mavelli, more

Life Sciences > 1998 > 63 > 19 > 1701-1713

When CBA male mice bearing TLX5 lymphoma were treated in the evening with a single i.v. dose of adriamycin (20-40 mg/Kg), the administration of a single pharmacological dose of melatonin (10 mg/kg s.c.) 1 hr earlier reduced the acute mortality from 1024 to 224. The increase in survival time caused by adriamycin over drug untreated controls was not reduced by melatonin. The administration of melatonin...

article

Seasonal effects of rotational stress on Lewis lung carcinoma metastasis and T-lymphocyte subsets in mice

Laura Perissin, Sonia Zorzet, Valentina Rapozzi, Renato Carignola, more

Life Sciences > 1998 > 63 > 9 > 711-719

Rotational stress specifically increases the formation of spontaneous lung metastasis in mice bearing Lewis lung carcinoma, without significantly modifying the growth of primary tumor. The increase in metastasis number and volume caused by rotational stress varies in magnitude with a highly significant circannual rhythm; the acrophase approximately coincides with summer solstice. Rotational stress...

article

Restraint Stress Reduces the Antitumor Efficacy of Cyclophosphamide in Tumor-Bearing Mice

Sonia Zorzet, Laura Perissin, Valentina Rapozzi, Tullio Giraldi

Brain Behavior and Immunity > 1998 > 12 > 1 > 23-33

Treatment with the cytotoxic antitumor drug cyclophosphamide is highly effective in mice bearing Lewis lung carcinoma, causing the absence of macroscopically detectable tumors at necroscopy after sacrifice. When the effects of the treatment on survival are determined, a significant increase in survival time and in the proportion of long-term survivors is observed. When restraint stress is further...

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Search results for: Valentina Rapozzi

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