Jamison J. Grailer

article

Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome

Yong Zhang, Xiru Li, Jamison J. Grailer, Na Wang, more

Journal of Pineal Research > 60 > 4 > 405 - 414

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are clinically severe respiratory disorders, and there are currently no Food and Drug Administration–approved drug therapies. Melatonin is a well‐known anti‐inflammatory molecule, which has proven to be effective in ALI induced by many conditions. Emerging studies suggest that the NLRP3 inflammasome plays a critical role during...

article

Organ distribution of histones after intravenous infusion of FITC histones or after sepsis

Fatemeh Fattahi, Jamison J. Grailer, Lawrence Jajou, Firas S. Zetoune, more

Immunologic Research > 2015 > 61 > 3 > 177-186

Histones appear in plasma during infectious or non-infectious sepsis and are associated with multiorgan injury. In the current studies, intravenous infusion of histones resulted in their localization in major organs. In vitro exposure of mouse macrophages to histones caused a buildup of histones on cell membranes followed by localization into cytosol and into the nucleus. After polymicrobial sepsis...

article

Inhibition of junctional adhesion molecule-A/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia/reperfusion injury

Nikola Sladojevic, Svetlana M. Stamatovic, Richard F. Keep, Jamison J. Grailer, more

Neurobiology of Disease > 2014 > 67 > Complete > 57-70

Proinflammatory mediators trigger intensive postischemic inflammatory remodeling of the blood–brain barrier (BBB) including extensive brain endothelial cell surface and junctional complex changes. Junctional adhesion molecule-A (JAM-A) is a component of the brain endothelial junctional complex with dual roles: paracellular route occlusion and regulating leukocyte docking and migration. The current...

article

Acute lung injury and the role of histones

Peter A Ward, Jamison J Grailer

Translational Respiratory Medicine > 2014 > 2 > 1 > 1-4

Acute respiratory distress syndrome (ARDS) in humans involves ≥ 200,000 individuals in the United States, and has a mortality rate (40%) for which no specific drug has been approved for use in humans. We have studied experimental acute lung injury (ALI) in mice following airway deposition of bacterial lipopolysaccharide (LPS) or the recombinant mouse complement anaphylatoxin, C5a. As ALI developed...

article

cRGD-functionalized, DOX-conjugated, and 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging

Xiaoqiang Yang, Hao Hong, Jamison J. Grailer, Ian J. Rowland, more

Biomaterials > 2011 > 32 > 17 > 4151-4160

Multifunctional and water-soluble superparamagnetic iron oxide (SPIO) nanocarriers were developed for targeted drug delivery and positron emission tomography/magnetic resonance imaging (PET/MRI) dual-modality imaging of tumors with integrin α _v β ₃ expression. An anticancer drug was conjugated onto the PEGylated SPIO nanocarriers via pH-sensitive bonds. Tumor-targeting ligands, cyclo(Arg-Gly-Asp-d-Phe-Cys)...

article

Multifunctional SPIO/DOX-loaded wormlike polymer vesicles for cancer therapy and MR imaging

Xiaoqiang Yang, Jamison J. Grailer, Ian J. Rowland, Alireza Javadi, more

Biomaterials > 2010 > 31 > 34 > 9065-9073

Stable and tumor-targeting multifunctional wormlike polymer vesicles simultaneously loaded with superparamagnetic iron oxide (SPIO) nanoparticles (NPs) as magnetic resonance imaging (MRI) contrast agent and anticancer drug doxorubicin (DOX) were developed for targeted cancer therapy and ultrasensitive MR imaging. These multifunctional wormlike polymer vesicles were formed by heterobifunctional amphiphilic...

article

Multifunctional Stable and pH-Responsive Polymer Vesicles Formed by Heterofunctional Triblock Copolymer for Targeted Anticancer Drug Delivery and Ultrasensitive MR Imaging

Xiaoqiang Yang, Jamison J. Grailer, Ian J. Rowland, Alireza Javadi, more

ACS Nano > 2010 > 4 > 11 > 6805 - 6817

article

Tumor-Targeting, pH-Responsive, and Stable Unimolecular Micelles as Drug Nanocarriers for Targeted Cancer Therapy

Xiaoqiang Yang, Jamison J. Grailer, Srikanth Pilla, Douglas A. Steeber, more

Bioconjugate Chemistry > 2010 > 21 > 3 > 496 - 504

article

L-selectin: Role in regulating homeostasis and cutaneous inflammation

Jamison J. Grailer, Masanari Kodera, Douglas A. Steeber

Journal of Dermatological Science > 2009 > 56 > 3 > 141-147

The maintenance of immune surveillance and the generation of normal immune responses are dependent on leukocyte migration to appropriate lymphoid and non-lymphoid tissues. The process of leukocyte migration occurs through complex and highly regulated interactions between the circulating leukocytes and the vascular endothelium. Multiple families of adhesion molecules as well as specific chemoattractants...

article

Biodegradable hydrogels based on novel photopolymerizable guar gum–methacrylate macromonomers for in situ fabrication of tissue engineering scaffolds

Ashutosh Tiwari, Jamison J. Grailer, Srikanth Pilla, Douglas A. Steeber, more

Acta Biomaterialia > 2009 > 5 > 9 > 3441-3452

Guar gum (GG) is a non-ionic polysaccharide that is found abundantly in nature and has many properties desirable for biomedical applications. In the present work GG with molecular weights ranging from 74 to 210kDa was modified with glycidyl methacrylate (GMA) to produce a series of water-soluble photopolymerizable guar gum–methacrylate (GG–MA) macromonomers of different molecular weights. We investigated...

article

Amphiphilic multi-arm-block copolymer conjugated with doxorubicin via pH-sensitive hydrazone bond for tumor-targeted drug delivery

Mani Prabaharan, Jamison J. Grailer, Srikanth Pilla, Douglas A. Steeber, more

Biomaterials > 2009 > 30 > 29 > 5757-5766

Folate-conjugated unimolecular micelles based on amphiphilic hyperbranched block copolymer, Boltorn ^® H40-poly(l-aspartate-doxorubicin)-b-poly(ethylene glycol)/FA-conjugated poly(ethylene glycol) (H40-P(LA-DOX)-b-PEG-OH/FA), were synthesized as a carrier for tumor-targeted drug delivery. The anticancer drug DOX was covalently conjugated onto the hydrophobic segments of the amphiphilic block...

article

Gold nanoparticles with a monolayer of doxorubicin-conjugated amphiphilic block copolymer for tumor-targeted drug delivery

Mani Prabaharan, Jamison J. Grailer, Srikanth Pilla, Douglas A. Steeber, more

Biomaterials > 2009 > 30 > 30 > 6065-6075

Gold (Au) nanoparticles (NPs) stabilized with a monolayer of folate-conjugated poly(l-aspartate-doxorubicin)-b-poly(ethylene glycol) copolymer (Au-P(LA-DOX)-b-PEG-OH/FA) was synthesized as a tumor-targeted drug delivery carrier. The Au-P(LA-DOX)-b-PEG-OH/FA NPs consist of an Au core, a hydrophobic poly(l-aspartate-doxorubicin) (P(LA-DOX)) inner shell, and a hydrophilic poly(ethylene glycol) and folate-conjugated...

article

Folate-conjugated amphiphilic hyperbranched block copolymers based on Boltorn® H40, poly(l-lactide) and poly(ethylene glycol) for tumor-targeted drug delivery

Mani Prabaharan, Jamison J. Grailer, Srikanth Pilla, Douglas A. Steeber, more

Biomaterials > 2009 > 30 > 16 > 3009-3019

Folate-conjugated amphiphilic hyperbranched block copolymer (H40–PLA-b-MPEG/PEG–FA) with a dendritic Boltorn ^® H40 core, a hydrophobic poly(l-lactide) (PLA) inner shell and a hydrophilic methoxy poly(ethylene glycol) (MPEG) and folate-conjugated poly(ethylene glycol) (PEG–FA) outer shell was synthesized as a carrier for tumor-targeted drug delivery. The block copolymer was characterized using...

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Search results for: Jamison J. Grailer

Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome

Organ distribution of histones after intravenous infusion of FITC histones or after sepsis

Inhibition of junctional adhesion molecule-A/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia/reperfusion injury

Acute lung injury and the role of histones

cRGD-functionalized, DOX-conjugated, and 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging

Multifunctional SPIO/DOX-loaded wormlike polymer vesicles for cancer therapy and MR imaging

Multifunctional Stable and pH-Responsive Polymer Vesicles Formed by Heterofunctional Triblock Copolymer for Targeted Anticancer Drug Delivery and Ultrasensitive MR Imaging

Tumor-Targeting, pH-Responsive, and Stable Unimolecular Micelles as Drug Nanocarriers for Targeted Cancer Therapy

L-selectin: Role in regulating homeostasis and cutaneous inflammation

Biodegradable hydrogels based on novel photopolymerizable guar gum–methacrylate macromonomers for in situ fabrication of tissue engineering scaffolds

Amphiphilic multi-arm-block copolymer conjugated with doxorubicin via pH-sensitive hydrazone bond for tumor-targeted drug delivery

Gold nanoparticles with a monolayer of doxorubicin-conjugated amphiphilic block copolymer for tumor-targeted drug delivery

Folate-conjugated amphiphilic hyperbranched block copolymers based on Boltorn® H40, poly(l-lactide) and poly(ethylene glycol) for tumor-targeted drug delivery

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