Search results for: Mikako Ogawa

Items from 1 to 20 out of 54 results

article

Food companies' perception of Japanese Food Safety Certification recognized by the Global Food Safety Initiative: Current state of program diffusion and future issues

Takashi Matsumoto, Mikako Ogawa

Journal of Food Safety > 41 > 6 > n/a - n/a

JFS‐C was acknowledged as a Global Food Safety Initiative (GFSI)‐recognized certification program in October 2018, and the number of sites certified for Japanese Food Safety Certification (JFS‐C) has been increasing. In this study, 34 out of 50 JFS‐C‐certified sites were surveyed, and responses were obtained. The questionnaire surveys were primarily conducted to investigate the purpose of JFS‐C certification...

article

From the respective expert viewpoints of the ANM specialty editors

Masayuki Inubushi, Miho Shidahara, Yasuyuki Takahashi, Mikako Ogawa, more

Annals of Nuclear Medicine > 2019 > 33 > 12 > 877-880

Although it may not be well known, the Annals of Nuclear Medicine (ANM) Editorial Committee includes one specialty editor of nuclear medicine physics, one of nuclear medicine technology, one of molecular imaging, and two of radiopharmacology. In addition, a statistics editor and a language editor are also on the committee. Manuscripts submitted to ANM can be peer-reviewed by such specialty editors...

article

Accumulation of hypoxia imaging probe “¹⁸F-FMISO” in macrophages depends on macrophage polarization in addition to hypoxic state

Yoichi Shimizu, Arata Motomura, Hideo Takakura, Nagara Tamaki, more

Annals of Nuclear Medicine > 2019 > 33 > 5 > 362-367

Objective Macrophages play an essential role in immune response, and are closely related to the progression of diseases such as cancer and atherosclerosis. Macrophages polarize to M1 or M2 type, which is related to the environmental hypoxic state. Previously, we found that ¹⁸F-FMISO uptake varied according to expression levels of biomolecules such as glutathione S-transferase P1 (GST-P1), which catalyzes...

article

Anti PD-1 treatment increases [¹⁸F]FDG uptake by cancer cells in a mouse B16F10 melanoma model

Mayu Tomita, Hironobu Yasui, Kei Higashikawa, Kohei Nakajima, more

EJNMMI Research > 2018 > 8 > 1 > 1-8

Background Programmed cell death 1 (PD-1) inhibitors act as immune checkpoint inhibitors and are more effective for improving survival time with less toxicity as compared with conventional chemotherapies. In anti PD-1 therapy, it is important to evaluate metabolism in the cancer microenvironment, as this helps to clarify the pathological conditions. Herein, we investigate the early effects of PD-1...

article

A Novel PET Probe “[¹⁸F]DiFA” Accumulates in Hypoxic Region via Glutathione Conjugation Following Reductive Metabolism

Yoichi Shimizu, Songji Zhao, Hironobu Yasui, Ken-ichi Nishijima, more

Molecular Imaging and Biology > 2019 > 21 > 1 > 122-129

Purpose Hypoxia in tumor has close relationship with angiogenesis and tumor progression. Previously, we developed 2,2-dihydroxymethyl-3-[¹⁸F]fluoropropyl-2-nitroimidazole ([¹⁸F]DiFA) as a novel positron emission tomography (PET) probe for diagnosis of hypoxia. In this study, we elucidated whether the accumulation of [¹⁸F]DiFA in cells is dependent on the hypoxic state and revealed how [¹⁸F]DiFA accumulates...

article

Immunoglobulin G (IgG)-Based Imaging Probe Accumulates in M1 Macrophage-Infiltrated Atherosclerotic Plaques Independent of IgG Target Molecule Expression

Yoichi Shimizu, Hiroko Hanzawa, Yan Zhao, Sagiri Fukura, more

Molecular Imaging and Biology > 2017 > 19 > 4 > 531-539

Purpose Vulnerable plaques are key factors for ischemic diseases. Thus, their precise detection is necessary for the diagnosis of such diseases. Immunoglobulin G (IgG)-based imaging probes have been developed for imaging biomolecules related to plaque formation for the diagnosis of atherosclerosis. However, IgG accumulates nonspecifically in atherosclerotic regions, and its accumulation mechanisms...

article

Monoclonal antibody-based optical molecular imaging probes; considerations and caveats in chemistry, biology and pharmacology

Hisataka Kobayashi, Peter L Choyke, Mikako Ogawa

Current Opinion in Chemical Biology > 2016 > 33 > C > 32-38

The monoclonal antibody (mAb) has proven to be a good platform for designing specific molecular imaging probes due to its superior binding specificity. Several optical imaging probes have been developed for surgical navigation in patients and are in early phase clinical trials. However, an inherent limitation of using the mAb is its pharmacokinetics which result in a prolonged circulating half-life...

article

Optimization of dendrimer structure for sentinel lymph node imaging: Effects of generation and terminal group

Yuichiro Niki, Mikako Ogawa, Rie Makiura, Yasuhiro Magata, more

Nanomedicine: Nanotechnology, Biology, and Medicine > 2015 > 11 > 8 > 2119-2127

The detection of the sentinel lymph node (SLN), the first lymph node draining tumor cells, is important in cancer diagnosis and therapy. Dendrimers are synthetic macromolecules with highly controllable structures, and are potent multifunctional imaging agents. In this study, 12 types of dendrimer of different generations (G2, G4, G6, and G8) and different terminal groups (amino, carboxyl, and acetyl)...

article

Development of radioiodinated lipophilic cationic compounds for myocardial imaging

Toshihiro Sakai, Yuriko Saito, Misato Takashima, Mikako Ogawa, more

Nuclear Medicine and Biology > 2015 > 42 > 5 > 482-487

Tc-99m compounds are mainly used in myocardial blood flow studies. These compounds, however, are produced by a generator and alternate single photon emission computed tomography (SPECT) radiopharmaceuticals are therefore required to avoid the risks posed by generator failure. Three radiolabeled compounds, including [¹²⁵I]p-iodobenzyl triphenylphosphonium ([¹²⁵I]ITPP), [¹²⁵I]p-Iodobenzyl dipropylphenylphosphonium...

article

PEG modification on 111In-labeled phosphatidyl serine liposomes for imaging of atherosclerotic plaques

Mikako Ogawa, Ryuji Uchino, Ayumi Kawai, Mutsumi Kosugi, more

Nuclear Medicine and Biology > 2015 > 42 > 3 > 299-304

Previously, we reported a probe for imaging of atherosclerotic plaques: ¹¹¹In-labeled liposomes. Liposomes were modified with phosphatidylserine (PS) because macrophages recognize PS and phagocytize apoptotic cells in plaques. PS modification was successful and we could visualize atherosclerotic plaques by single-photon emission computed tomography (SPECT). However, too-rapid blood clearance reduced...

article

Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [¹¹C]CB184 and [¹¹C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [¹¹C](R)-PK11195

Kentaro Hatano, Katsuhiko Sekimata, Takashi Yamada, Junichiro Abe, more

Annals of Nuclear Medicine > 2015 > 29 > 4 > 325-335

Objective We report synthesis of two carbon-11 labeled imidazopyridines TSPO ligands, [¹¹C]CB184 and [¹¹C]CB190, for PET imaging of inflammatory process along with neurodegeneration, ischemia or brain tumor. Biodistribution of these compounds was compared with that of [¹¹C]CB148 and [¹¹C](R)-PK11195. Methods Both [¹¹C]CB184 and [¹¹C]CB190 having ¹¹C-methoxyl group on an aromatic ring were readily...

article

Prolonged local retention of subcutaneously injected polymers monitored by noninvasive SPECT imaging

Chie Kojima, Yuichiro Niki, Mikako Ogawa, Yasuhiro Magata

International Journal of Pharmaceutics > 2014 > 476 > 1-2 > 164-168

Polymers are widely applied to drug delivery systems because polymers are generally excreted from the body more slowly than small molecules. Subcutaneous injection is one plausible means of administration. In this study, the in vivo behaviors of subcutaneously injected polymers, linear poly(glutamic acid) (Poly-Glu), acetylated dendrimer (Ac-den) and collagen peptide-conjugated dendrimer (CP-den),...

article

Radiolabeled γ-polyglutamic acid complex as a nano-platform for sentinel lymph node imaging

Kohei Sano, Yuriko Iwamiya, Tomoaki Kurosaki, Mikako Ogawa, more

Journal of Controlled Release > 2014 > 194 > C > 310-315

We established a ternary anionic complex constructed with polyamidoamine dendrimer (4th generation; G4) modified with chelating agents (diethylenetriamine pentaacetic acid (DTPA) derivative), polyethyleneimine (PEI), and γ-polyglutamic acid (PGA) as a safe nano-platform for molecular imaging. We prepared indium-111-labeled DTPA-G4/PEI/γ-PGA, and evaluated the effectiveness as a nuclear imaging probe...

article

¹⁸F-FDG PET and intravascular ultrasonography (IVUS) images compared with histology of atherosclerotic plaques: ¹⁸F-FDG accumulates in foamy macrophages

Seigo Ishino, Mikako Ogawa, Ikuo Mori, Satoshi Nishimura, more

European Journal of Nuclear Medicine and Molecular Imaging > 2014 > 41 > 4 > 624-633

Purpose Intravascular ultrasonography (IVUS) and ¹⁸F-FDG PET have been used to evaluate the efficacy of antiatherosclerosis drugs. These two modalities image different characteristics of atherosclerotic plaques, and a comparison of IVUS and PET images with histology has not been performed. The aim of this study was to align IVUS and PET images using anatomic landmarks in Watanabe heritable hyperlipidaemic...

article

Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4

Nobuya Kurabe, Takahiro Hayasaka, Mikako Ogawa, Noritaka Masaki, more

Cancer Science > 104 > 10 > 1295 - 1302

The identification of cancer biomarkers is critical for target‐linked cancer therapy. The overall level of phosphatidylcholine (PC) is elevated in colorectal cancer (CRC). To investigate which species of PC is overexpressed in colorectal cancer, an imaging mass spectrometry was performed using a panel of non‐neoplastic mucosal and CRC tissues. In the present study, we identified a novel biomarker,...

article

Doxorubicin-conjugated dendrimer/collagen hybrid gels for metastasis-associated drug delivery systems

Chie Kojima, Tomoyuki Suehiro, Kenji Watanabe, Mikako Ogawa, more

Acta Biomaterialia > 2013 > 9 > 3 > 5673-5680

Metastasis is a characteristic property of cancer cells, which degrade extracellular matrix containing collagen. We prepared a polymer prodrug-embedded collagen gel for metastasis-associated drug delivery. A collagen peptide-modified dendrimer that attached doxorubicin (Dox) via a pH-degradable linkage was synthesized as a polymer prodrug. Compared with free Dox, the diffusion of the dendrimer prodrug...

article

Anti-HMGB1 antibody attenuates vascular hyperpermeability and promotes wound healing during ischemia-reperfusion injury model in mouse skin

Akira Kasuya, Satoshi Hirakawa, Keyue Liu, Akihiro Kishimura, more

Journal of Dermatological Science > 2013 > 69 > 2 > e59

article

Differentiation of tumor sensitivity to photodynamic therapy and early evaluation of treatment effect by nuclear medicine techniques

Jie Liu, Mikako Ogawa, Toshihiro Sakai, Misato Takashima, more

Annals of Nuclear Medicine > 2013 > 27 > 7 > 669-675

Objective Our final goal is to develop an appropriate method using nuclear medicine technique for monitoring the effect and prediction of Photodynamic Therapy (PDT) on tumors. The aim of this study is to evaluate the effect of PDT on tumor cells in vitro using ¹⁸F-FDG and ^99mTc-MIBI as tracers. Methods Five tumor cell lines (A431, DU145, H1650, LS180, SHIN3) with varied characteristics were irradiated...

article

Mo1544 Intraoperative Evaluation of Blood Perfusion of the Gastric Tube After Esophagectomy With Near-Infrared Fluorescence Imaging

Masaki Sano, Kinji Kamiya, Shinichirou Miyazaki, Naoki Unno, more

Gastroenterology > 2012 > 142 > 5 Supplement 1 > S-624-S-625

article

Dendrimer-based MRI contrast agents: the effects of PEGylation on relaxivity and pharmacokinetics

Chie Kojima, Baris Turkbey, Mikako Ogawa, Marcelino Bernardo, more

Nanomedicine: Nanotechnology, Biology, and Medicine > 2011 > 7 > 6 > 1001-1008

Polyethylene glycol (PEG) surface modification can make nanomaterials highly hydrophilic, reducing their sequestration in the reticuloendothelial system. In this study, polyamidoamine (PAMAM) dendrimers bearing gadolinium (Gd) chelates were PEGylated with different PEG-chain lengths, and the effects on paramagnetic and pharmacokinetic properties were evaluated. Specifically, Gd chelate-bearing PAMAM...

Publication date

Last 3 years (1)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

Content availability

Available (53)
None (1)

Keywords

PET (5)
POSITRON EMISSION TOMOGRAPHY (5)
ATHEROSCLEROSIS (4)
DENDRIMER (4)
CENTRAL NERVOUS SYSTEM (3)
MACROPHAGE (3)
NICOTINIC ACETYLCHOLINE RECEPTOR (3)
18F-FDG (2)
4-HYDROXY-2(1H)-QUINOLONE (2)
FLUORINE-18 (2)
HYPOXIA (2)
MOLECULAR IMAGING (2)
NMDA RECEPTOR (2)
NOCICEPTIN (2)
NOREPINEPHRINE TRANSPORTER (2)
OEF (2)
ORL1 RECEPTOR (2)
OXYGEN-15 (2)
POLARIZATION (2)
POSITRON (2)
RADIOSYNTHESIS (2)
RAT (2)
SENTINEL LYMPH NODE (2)
SPECT (2)
[18F]FDG (2)
[ 1 1 C]CPEB (1)
[ 1 2 5 I]MIBG (1)
[ 1 8 F]FDG (1)
[ 9 9 M TC]MIBI (1)
Α V Β 3 INTEGRIN (1)
99MTC-MIBI (1)
18F-FMISO (1)
18F-LABELED BORON-DERIVED METHIONINE ANALOGUE (18F-B-MET) (1)
2-DEOXY-2-[18F]FLUORO-D-GLUCOSE (1)
5-IODO-A-85380 (5IA) (1)
5‐[125I]IODO‐A‐85380 ([125I]5IA) (1)
99MTC-MIBI (1)
AGING (1)
AGONIST SENSITIVITY (1)
ALPHA7 SUBTYPE (1)
ALZHEIMER DISEASE (1)
ALZHEIMER'S DISEASE (1)
ALZHEIMER’S DISEASE (1)
APOPTOSIS (1)
AUTORADIOGRAPHY (1)
BENZIMIDAZOLE (1)
BIODISTRIBUTION (1)
CATIONIC COMPOUND (1)
CEREBRAL ENERGY METABOLISM (1)
CHARGED PARTICLE (1)
COLLAGEN (1)
CORONARY PLAQUE (1)
DEPRESSION (1)
DESENSITIZATION (1)
DIFA (1)
DOPAMINE (1)
DOSIMETRY (1)
DRUG DELIVERY (1)
ENDOVASCULAR DETECTION (1)
EXTRACELLULAR CALCIUM ION (1)
FOAM CELLS (1)
GK RATS (1)
GLUCOSE (1)
GLUTAMATE TOXICITY (1)
GLUTATHIONE (1)
GLYCINE-BINDING SITE (1)
GLYCINE-SITE ANTAGONIST (1)
HARMONIC PET (1)
HYDROGEL (1)
IMAGING (1)
IMAGING AGENT (1)
IMAGING MASS SPECTROMETRY (1)
IMIDAZOPYRIDINEACETAMIDES (1)
IMMUNE CHECKPOINT INHIBITOR (1)
IMMUNOGLOBULIN G (1)
IN VIVO EVALUATION (1)
INTRAVASCULAR ULTRASONOGRAPHY (1)
ISCHEMIA (1)
LACTATE (1)
LIPOSOME (1)
LOX-1 (1)
M1 (1)
M2 (1)
MCP-1 (1)
META-[211AT]ASTATO-BENZYGUANIDINE (211AT-MABG) (1)
METASTASIS (1)
MMP-9 (1)
MOUSE MELANOMA (1)
MRI (1)
MULTIMODAL IMAGING (1)
MUSCARINIC ACETYLCHOLINE RECEPTOR (1)
MYOCARDIAL BLOOD FLOW (1)
NANOPARTICLE (1)
NBM-LESIONED RAT (1)
NEURODEGENERATIVE PROCESSES (1)
NEUROINFLAMMATION (1)
NEUROPROTECTION (1)
NICOTINIC ACETYLCHOLINE RECEPTOR Α7 SUBTYPE (1)
NON-INSULIN-DEPENDENT DIABETES MELLITUS (1)
NR2B SUBTYPE (1)
more

Data set

Elsevier (29)
Springer (11)
ACS (10)
Wiley (4)

Journal

Nuclear Medicine and Biology (11)
Bioconjugate Chemistry (6)
Annals of Nuclear Medicine (4)
European Journal of Nuclear Medicine and Molecular Imaging (4)
International Congress Series (3)
Bioorganic & Medicinal Chemistry (2)
Cancer Science (2)
Molecular Imaging and Biology (2)
Nanomedicine: Nanotechnology, Biology, and Medicine (2)
ACS Chemical Biology (1)
Acta Biomaterialia (1)
Atherosclerosis (1)
Biological Psychiatry (1)
Brain Research (1)
Chemical Reviews (1)
Current Opinion in Chemical Biology (1)
EJNMMI Research (1)
Gastroenterology (1)
International Journal of Pharmaceutics (1)
Journal of Controlled Release (1)
Journal of Dermatological Science (1)
Journal of Food Safety (1)
Journal of Medicinal Chemistry (1)
Molecular Pharmaceutics (1)
Neuroscience Research (1)
Synapse (1)
The Lancet Oncology (1)
more

INFONA - science communication portal

Search results for: Mikako Ogawa

Food companies' perception of Japanese Food Safety Certification recognized by the Global Food Safety Initiative: Current state of program diffusion and future issues

From the respective expert viewpoints of the ANM specialty editors

Accumulation of hypoxia imaging probe “¹⁸F-FMISO” in macrophages depends on macrophage polarization in addition to hypoxic state

Anti PD-1 treatment increases [¹⁸F]FDG uptake by cancer cells in a mouse B16F10 melanoma model

A Novel PET Probe “[¹⁸F]DiFA” Accumulates in Hypoxic Region via Glutathione Conjugation Following Reductive Metabolism

Immunoglobulin G (IgG)-Based Imaging Probe Accumulates in M1 Macrophage-Infiltrated Atherosclerotic Plaques Independent of IgG Target Molecule Expression

Monoclonal antibody-based optical molecular imaging probes; considerations and caveats in chemistry, biology and pharmacology

Optimization of dendrimer structure for sentinel lymph node imaging: Effects of generation and terminal group

Development of radioiodinated lipophilic cationic compounds for myocardial imaging

PEG modification on 111In-labeled phosphatidyl serine liposomes for imaging of atherosclerotic plaques

Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [¹¹C]CB184 and [¹¹C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [¹¹C](R)-PK11195

Prolonged local retention of subcutaneously injected polymers monitored by noninvasive SPECT imaging

Radiolabeled γ-polyglutamic acid complex as a nano-platform for sentinel lymph node imaging

¹⁸F-FDG PET and intravascular ultrasonography (IVUS) images compared with histology of atherosclerotic plaques: ¹⁸F-FDG accumulates in foamy macrophages

Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4

Doxorubicin-conjugated dendrimer/collagen hybrid gels for metastasis-associated drug delivery systems

Anti-HMGB1 antibody attenuates vascular hyperpermeability and promotes wound healing during ischemia-reperfusion injury model in mouse skin

Differentiation of tumor sensitivity to photodynamic therapy and early evaluation of treatment effect by nuclear medicine techniques

Mo1544 Intraoperative Evaluation of Blood Perfusion of the Gastric Tube After Esophagectomy With Near-Infrared Fluorescence Imaging

Dendrimer-based MRI contrast agents: the effects of PEGylation on relaxivity and pharmacokinetics

Filter options

Publication date

Content availability

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Mikako Ogawa

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options