Search results for: Ji Won Park

Items from 1 to 20 out of 218 results

article

Mutational evolution after chemotherapy‐progression in metastatic colorectal cancer revealed by circulating tumor DNA analysis

Sheehyun Kim, Yongjun Cha, Yoojoo Lim, Hanseong Roh, more

International Journal of Cancer > 153 > 3 > 571 - 583

Emerging new mutations after treatment can provide clues to acquired resistant mechanisms. Circulating tumor DNA (ctDNA) sequencing has enabled noninvasive repeated tumor mutational profiling. We aimed to investigate newly emerging mutations in ctDNA after disease progression in metastatic colorectal cancer (mCRC). Blood samples were prospectively collected from mCRC patients receiving palliative...

article

¹⁵N‐labeled dietary nitrate supplementation increases human skeletal muscle nitrate concentration and improves muscle torque production

Stefan Kadach, Ji Won Park, Zdravko Stoyanov, Matthew I. Black, more

Acta Physiologica > 237 > 3 > n/a - n/a

Aim Dietary nitrate (NO₃⁻) supplementation increases nitric oxide bioavailability and can enhance exercise performance. We investigated the distribution and metabolic fate of ingested NO₃⁻ at rest and during exercise with a focus on skeletal muscle. Methods In a randomized, crossover study, 10 healthy volunteers consumed 12.8 mmol ¹⁵N‐labeled potassium nitrate (K¹⁵NO₃; NIT) or potassium chloride...

article

Standard versus longer interval of radical resection after neoadjuvant chemoradiotherapy in locally advanced rectal cancer: A 20‐year single‐center experience & propensity‐score matching

Saule Khamzina, Jongoh Lee, Seung‐Bum Ryoo, Min Jung Kim, more

Journal of Surgical Oncology > 127 > 1 > 119 - 131

Background and Objectives Despite the standard interval of 6−8 weeks between neoadjuvant chemoradiotherapy (nCRT) and surgery, it is debated whether an interval of >8 weeks increases the pathologic complete response (pCR) rate. We investigated the interval between nCRT and surgery, and its impact on oncological outcomes and postoperative complications in patients with locally advanced rectal cancer...

article

Bedside risk‐scoring model for predicting 6‐week mortality in cirrhotic patients undergoing endoscopic band ligation for acute variceal bleeding

Jung Hee Kim, Se Woo Park, Jang Han Jung, Da Hae Park, more

Journal of Gastroenterology and Hepatology > 36 > 7 > 1935 - 1943

Background and Aim Acute variceal bleeding (AVB) is a fatal adverse event of cirrhosis, and endoscopic band ligation (EBL) is the standard treatment for AVB. We developed a novel bedside risk‐scoring model to predict the 6‐week mortality in cirrhotic patients undergoing EBL for AVB. Methods Cox regression analysis was used to assess the relationship of clinical, biological, and endoscopic variables...

article

Controlling Residual Lithium in High‐Nickel (>90 %) Lithium Layered Oxides for Cathodes in Lithium‐Ion Batteries

Won Mo Seong, Kwang‐Hwan Cho, Ji‐Won Park, Hyeokjun Park, more

Angewandte Chemie > 132 > 42 > 18821 - 18828

The rampant generation of lithium hydroxide and carbonate impurities, commonly known as residual lithium, is a practical obstacle to the mass‐scale synthesis and handling of high‐nickel (>90 %) layered oxides and their use as high‐energy‐density cathodes for lithium‐ion batteries. Herein, we suggest a simple in situ method to control the residual lithium chemistry of a high‐nickel lithium layered...

article

Controlling Residual Lithium in High‐Nickel (>90 %) Lithium Layered Oxides for Cathodes in Lithium‐Ion Batteries

Won Mo Seong, Kwang‐Hwan Cho, Ji‐Won Park, Hyeokjun Park, more

Angewandte Chemie International Edition > 59 > 42 > 18662 - 18669

article

Efficacy of health coaching and a web‐based program on physical activity, weight, and distress management among cancer survivors: A multi‐centered randomised controlled trial

Young Ho Yun, Cheol Il Lim, Eun Sook Lee, Young Tae Kim, more

Psycho‐Oncology > 29 > 7 > 1105 - 1114

Objectives To investigate the efficacy of health coaching and a web‐based program on survivor physical activity (PA), weight, and distress management among stomach, colon, lung and breast cancer patients. Methods This randomised, controlled, 1‐year trial conducted in five hospitals recruited cancer survivors within 2 months of completing primary cancer treatment who had not met ≥1 of these behavioural...

article

Biological acidification and beer quality: addition of lactic acid bacteria isolated from malt

Eun‐Ji Choi, Ji‐Won Park, Ji Hyeon Kim, Wang June Kim

Journal of the Institute of Brewing > 126 > 2 > 176 - 183

Two lactic acid bacteria, Pediococcus acidilactici HW01 and Leuconostoc citreum isolated from Pilsner malt, were added during mashing and the impact on fermentation examined. The pH of lactic acid bacteria supplemented (bioacidified) wort and finished beer were lower than that of the control. Bioacidified worts resulted in higher levels of free amino nitrogen, reducing sugars and alcohol in the corresponding...

article

Human skeletal muscle nitrate store: influence of dietary nitrate supplementation and exercise

Lee J. Wylie, Ji Won Park, Anni Vanhatalo, Stefan Kadach, more

The Journal of Physiology > 597 > 23 > 5565 - 5576

Key points Nitric oxide (NO), a potent vasodilator and a regulator of many physiological processes, is produced in mammals both enzymatically and by reduction of nitrite and nitrate ions. We have previously reported that, in rodents, skeletal muscle serves as a nitrate reservoir, with nitrate levels greatly exceeding those in blood or other internal organs, and with nitrate being reduced to NO during...

article

Synthesis and characterization of a new phosphorus‐containing furan‐based epoxy curing agent as a flame retardant

Mai Toan, Ji‐Won Park, Hyung‐Jun Kim, Seunghan Shin

Fire and Materials > 43 > 6 > 717 - 724

In this study, 5‐hydroxymethyl‐2‐furfural (HMF) was used as a renewable resource for preparing an epoxy curing agent (furan‐based flame retardant, FBF), and a phosphorus‐containing functional group was also incorporated to enhance the flame retardancy of FBF. FBF was easily synthesized, and the total yield was 83%. 2‐Methyl imidazole was chosen as an accelerant to reduce the activation energy for...

article

Comparison of responsiveness to cancer development and anti-cancer drug in three different C57BL/6N stocks

Mi Ju Kang, Ji Eun Kim, Ji Won Park, Hyeon Jun Choi, more

Laboratory Animal Research > 2019 > 35 > 1 > 1-10

In our efforts to understand the systemic features of tumors, the importance of animal models is increasing due to the recent growth in the development of immunotherapy and targeted therapies. This has resulted in increased attention towards tumor animal models using C57BL/6N, which are mainly used in immunological studies. In this study, the C57BL/6NKorl stock and two other commercial stocks (C57BL/6NA...

article

Oncologic Risk of Rectal Preservation Against Medical Advice After Chemoradiotherapy for Rectal Cancer: A Multicenter Comparative Cross-Sectional Study with Rectal Preservation as Supported by Surgeon

Kwang-Seop Song, Sung Chan Park, Dae Kyung Sohn, Jae Hwan Oh, more

World Journal of Surgery > 2019 > 43 > 12 > 3216-3223

Background Rectal preservation against medical advice after neoadjuvant chemoradiotherapy for rectal cancer may increase oncologic uncertainty. This study aimed to compare the oncologic outcomes of patients undergoing rectal preservation as intended by the surgeon, and the outcomes of patients refusing rectal resection against medical advice. Methods The study population consisted of patients in...

article

Drug holiday patterns and bisphosphonate‐related osteonecrosis of the jaw

Sun‐Young Jung, Hae Sun Suh, Ji‐Won Park, Jin‐Won Kwon

Oral Diseases > 25 > 2 > 471 - 480

Objectives There is limited evidence regarding the appropriate length of a bisphosphonate (BP) holiday to reduce the risk of osteonecrosis of the jaw (ONJ). In this cross‐sectional study, we investigated the population‐based patterns of the gaps between BP discontinuation and ONJ diagnosis. Subjects and Methods We used the claims database of the National Health Insurance Service in Korea. Among...

article

Oncologic outcomes after adjuvant chemotherapy with capecitabine compared to 5-fluorouracil/leucovorin for geriatric stage II colon cancer: a retrospective cohort study

Kil-yong Lee, Ji Won Park, Ki-young Lee, Sangsik Cho, more

International Journal of Colorectal Disease > 2019 > 34 > 4 > 629-639

Purpose After curative resection of stage II colon cancer, adjuvant chemotherapy with 5-fluorouracil/leucovorin (FL) or capecitabine is selectively recommended. However, there is little evidence of the effect of capecitabine on oncologic outcome in geriatric patients with stage II colon cancer compared to that of FL. The aim of this study was to determine the difference in recurrence-free survival...

article

Metabolomics approach to serum biomarker for laxative effects of red Liriope platyphylla in loperamide-induced constipation of SD rats

Ji Eun Kim, Young Ju Lee, Sung Ha Ryu, Ji Won Park, more

Laboratory Animal Research > 2019 > 35 > 1 > 1-9

Red Liriope platyphylla (RLP) is a known herbal medicine used in the treatment of some chronic diseases including constipation, neurodegenerative disorders, diabetes and obesity. To determine and characterize putative biomarkers that predict the laxative effects induced by RLP treatment, alteration of endogenous metabolites was measured in the serum of loperamide (Lop)-induced constipation rats after...

article

Prognostic significance of sealed-off perforation in colon cancer: a prospective cohort study

Kil-yong Lee, Ji Won Park, Inho Song, Ki-young Lee, more

World Journal of Surgical Oncology > 2018 > 16 > 1 > 1-8

Background Perforated colon cancer is a rare complication, but has a high risk of recurrence. However, most studies have not distinguished sealed-off perforation from free perforation, and the prognosis is unclear. The aim of this study was to evaluate the oncologic outcome of colon cancer with sealed-off perforation. Methods Eighty-six consecutive patients who underwent resection for colon cancer...

article

Cellular Delivery of siRNA Using Poly(2-dimethylaminoethyl methacrylate)- Functionalized Graphene Oxide Nano-Wrap

Jung Eun Lee, Kyuri Lee, Jeong A. Nam, Aesun Kim, more

Macromolecular Research > 2018 > 26 > 12 > 1115-1122

Despite its high therapeutic potential, the use of siRNA has still been limited mostly due to the lack of a proper delivery system. Small number of charges and inflexible structure of siRNA are the major factors that affect cellular delivery efficiency of conventional lipid and polymeric carriers. In this study, we synthesized a 2-dimensional (2D) carrier for siRNA using a facile method to functionalize...

article

Colorectal cancer susceptibility loci and influence on survival

Nan Song, Kyeezu Kim, Aesun Shin, Ji Won Park, more

Genes, Chromosomes and Cancer > 57 > 12 > 630 - 637

Genome‐wide association studies (GWAS) have identified multiple single‐nucleotide polymorphisms (SNPs) associated with colorectal cancer risk. To evaluate the potential influence of colorectal cancer susceptibility SNPs on disease prognosis, we investigated whether GWAS‐identified colorectal cancer risk SNPs and polygenic risk scores (PRSs) might be associated with survival among colorectal cancer...

article

First report of nocardia infection in cultured Japanese eel, Anguilla japonica

Bo Seong Kim, Ji Won Park, Gyoung Sik Kang, Ji Hye Jin, more

Journal of Fish Diseases > 41 > 12 > 1921 - 1927

article

Laparoscopic approach for left-sided T4 colon cancer is a safe and feasible procedure, compared to open surgery

Jung Ho Park, Hyoung-Chul Park, Sung Chan Park, Dae Kyung Sohn, more

Surgical Endoscopy > 2019 > 33 > 9 > 2843-2849

Background A laparoscopic approach can be attempted for pathologic T4 (pT4) colon cancer. Our aim was to evaluate the clinico-oncologic outcomes following laparoscopic versus open surgery for right and left-sided pT4 colon cancer. Methods From a multicentric collaborative database, we enrolled 245 patients with right-sided colon cancer (RCC, 128 laparoscopy and 117 open) and 338 with left-sided...

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RECTAL CANCER (16)
COLORECTAL CANCER (12)
ADHESION PERFORMANCE (7)
PREOPERATIVE CHEMORADIOTHERAPY (6)
MUC5AC (5)
NITRIC OXIDE (5)
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ASTHMA (2)
BARIUM OXIDE (2)
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INFONA - science communication portal

Search results for: Ji Won Park

Mutational evolution after chemotherapy‐progression in metastatic colorectal cancer revealed by circulating tumor DNA analysis

¹⁵N‐labeled dietary nitrate supplementation increases human skeletal muscle nitrate concentration and improves muscle torque production

Standard versus longer interval of radical resection after neoadjuvant chemoradiotherapy in locally advanced rectal cancer: A 20‐year single‐center experience & propensity‐score matching

Bedside risk‐scoring model for predicting 6‐week mortality in cirrhotic patients undergoing endoscopic band ligation for acute variceal bleeding

Controlling Residual Lithium in High‐Nickel (>90 %) Lithium Layered Oxides for Cathodes in Lithium‐Ion Batteries

Controlling Residual Lithium in High‐Nickel (>90 %) Lithium Layered Oxides for Cathodes in Lithium‐Ion Batteries

Efficacy of health coaching and a web‐based program on physical activity, weight, and distress management among cancer survivors: A multi‐centered randomised controlled trial

Biological acidification and beer quality: addition of lactic acid bacteria isolated from malt

Human skeletal muscle nitrate store: influence of dietary nitrate supplementation and exercise

Synthesis and characterization of a new phosphorus‐containing furan‐based epoxy curing agent as a flame retardant

Comparison of responsiveness to cancer development and anti-cancer drug in three different C57BL/6N stocks

Oncologic Risk of Rectal Preservation Against Medical Advice After Chemoradiotherapy for Rectal Cancer: A Multicenter Comparative Cross-Sectional Study with Rectal Preservation as Supported by Surgeon

Drug holiday patterns and bisphosphonate‐related osteonecrosis of the jaw

Oncologic outcomes after adjuvant chemotherapy with capecitabine compared to 5-fluorouracil/leucovorin for geriatric stage II colon cancer: a retrospective cohort study

Metabolomics approach to serum biomarker for laxative effects of red Liriope platyphylla in loperamide-induced constipation of SD rats

Prognostic significance of sealed-off perforation in colon cancer: a prospective cohort study

Cellular Delivery of siRNA Using Poly(2-dimethylaminoethyl methacrylate)- Functionalized Graphene Oxide Nano-Wrap

Colorectal cancer susceptibility loci and influence on survival

First report of nocardia infection in cultured Japanese eel, Anguilla japonica

Laparoscopic approach for left-sided T4 colon cancer is a safe and feasible procedure, compared to open surgery

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