Search results for: Sun Hwa Kim

Items from 1 to 20 out of 98 results

article

Light‐Triggered PROTAC Nanoassemblies for Photodynamic IDO Proteolysis in Cancer Immunotherapy (Adv. Mater. 38/2024)

Jiwoong Choi, Byeongmin Park, Jung Yeon Park, Dongwon Shin, more

Advanced Materials > 36 > 38 > n/a - n/a

Cancer Immunotherapy Man Kyu Shim, Yongju Kim, Yoosoo Yang, and colleagues develope a light‐triggered proteolysis‐targeting chimera (PROTAC) nanoassembly. This nanoassembly accumulates significantly in tumor tissues, triggering a burst release of active PROTACs. Upon light irradiation, tumor cells undergo immunogenic cell death to promote T cell activation, while the recyclable action of the PROTACs...

article

Light‐Triggered PROTAC Nanoassemblies for Photodynamic IDO Proteolysis in Cancer Immunotherapy

Jiwoong Choi, Byeongmin Park, Jung Yeon Park, Dongwon Shin, more

Advanced Materials > 36 > 38 > n/a - n/a

While proteolysis‐targeting chimeras (PROTACs) hold great potential for persistently reprogramming the immunosuppressive tumor microenvironment via targeted protein degradation, precisely activating them in tumor tissues and preventing uncontrolled proteolysis at off‐target sites remain challenging. Herein, a light‐triggered PROTAC nanoassembly (LPN) for photodynamic indoleamine 2,3‐dioxygenase (IDO)...

article

Market potential and value‐added opportunities of cold‐hardy berries and small fruits in the Intermountain West, USA

Sumedha Garg, Rachel Leisso, Sun‐Hwa Kim, Emily Mayhew, more

Journal of Food Science > 88 > 2 > 860 - 876

Abstract Novel cold‐hardy berries and small fruits represent an opportunity for growers in the Intermountain West, USA, as the harsh environment is not suited for other common berries and small fruits. This study analyzed the fresh market and value‐added potential of haskap berries (Lonicera caerulea), saskatoon berries (Amelenchier alnifolia), and dwarf sour cherry (DSC) fruit (Prunus x kerrasis...

article

Sustained Exosome‐Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and MiRNAs, and Sustained Release Formulation

Gijung Kwak, Jing Cheng, Hyosuk Kim, Sukyung Song, more

Small > 18 > 15 > n/a - n/a

Macrophages (Mφs) are characterized by remarkable plasticity, an essential component of chronic inflammation. Thus, an appropriate and timely transition from proinflammatory (M1) to anti‐inflammatory (M2) Mφs during wound healing is vital to promoting resolution of acute inflammation and enhancing tissue repair. Herein, exosomes derived from M2‐Mφs (M2‐Exos), which contain putative key regulators...

article

Information Risk and Debtholders’ Mispricing by Considering Audit Quality*

Yong‐Ki Jung, Sun‐Hwa Kim

Asia‐Pacific Journal of Financial Studies > 49 > 3 > 463 - 508

We examine how audit quality perceptions impact debt mispricing in the presence of earnings management. The Big Four auditors (BFAs) and auditor tenure are used as proxies for perceptions of higher quality audits. Debt mispricing means that debtholders charge a lower (higher) cost of debt to a firm with low (high) accrual earnings management (AEM) and high (low) real earnings management (REM). We...

article

Combination of bisacodyl suppository and 1 L polyethylene glycol plus ascorbic acid is a non‐inferior and comfortable regimen compared to 2 L polyethylene glycol plus ascorbic acid

Sun Hwa Kim, Eun Ran Kim, Kyunga Kim, Tae Jun Kim, more

Digestive Endoscopy > 32 > 4 > 600 - 607

Background and Aim Appropriate bowel cleansing before colonoscopy is an important factor in increasing the detection rate of lesions. Low‐volume polyethylene glycol (PEG) plus ascorbic acid (PEG‐Asc) reduces the dosage of bowel preparation agent, but still presents discomfort to patients. The primary aim of the present study was to compare the efficacy of bowel cleansing between 2 L PEG‐Asc (control)...

article

Su1712 USEFULNESS OF BISACODYL SUPPOSITORY AGENT FOR VOLUME REDUCTION OF BOWEL PREPARATION AGENT

Sun Hwa Kim, Si Kyong Ryoo, Eun Ran Kim, Tae Jun Kim, more

Gastrointestinal Endoscopy > 2018 > 87 > 6(S) > AB382

article

Gene expression signatures after ethanol exposure in differentiating embryoid bodies

Chanchal Mandal, Sun Hwa Kim, Jin Choul Chai, Young Seek Lee, more

Toxicology in Vitro > 2018 > 46 > C > 66-76

During the differentiation process, various epigenetic factors regulate the precise expression of important genes and control cellular fate. During this stage, the differentiating cells become vulnerable to external stimuli. Here, we used an early neural differentiation model to observe ethanol-mediated transcriptional alterations. Our objective was to identify important molecular regulators of ethanol-related...

article

Memory loss and decreased executive function are associated with limited functional capacity in patients with heart failure compared to patients with other medical conditions

JinShil Kim, Mi-Seung Shin, Seon Young Hwang, Eunok Park, more

Heart & Lung: The Journal of Acute and Critical Care > 2018 > 47 > 1 > 61-67

There is limited evidence on the degree of cognitive impairment and its association with physical functional capacity among patients with heart failure (HF) in Korea.In this study, we compared cognitive impairment between patients with HF and community-dwelling participants with non-HF medical conditions (medical participants) and its association with physical functional capacity.We conducted a cross-sectional...

article

Synergistic antitumor effects of combination treatment with metronomic doxorubicin and VEGF-targeting RNAi nanoparticles

Gijung Kwak, Sung Duk Jo, Dongkyu Kim, Hyosuk Kim, more

Journal of Controlled Release > 2017 > 267 > C > 203-213

Conventional cancer treatment strategies have been aimed at eradicating all cancer cells. To this end, standard chemotherapeutic approaches have relied on the maximum tolerated dose (MTD) of cytotoxic drugs with a long off-therapy interval, leading to heavy toxic side effects accompanied by drug resistance. To avoid the problems associated with the traditional MTD chemotherapy, metronomic chemotherapy...

article

Rolling circle transcription-based polymeric siRNA nanoparticles for tumor-targeted delivery

Jae Hyeop Lee, Sook Hee Ku, Min Ju Kim, So Jin Lee, more

Journal of Controlled Release > 2017 > 263 > C > 29-38

RNA, one of the major biological macromolecules, has been considered as an attractive building material for bottom-up fabrication of nanostructures in the past few decades due to advancements in RNA biology, RNA chemistry and RNA nanotechnology. Most recently, an isothermal enzymatic nucleic acid amplification method termed rolling circle transcription (RCT), which achieves a large-scale synthesis...

article

Selective inhibition of EZH2 by a small molecule inhibitor regulates microglial gene expression essential for inflammation

Sarder Arifuzzaman, Amitabh Das, Sun Hwa Kim, Taeho Yoon, more

Biochemical Pharmacology > 2017 > 137 > C > 61-80

Multiple studies have documented that Enhancer of zeste homolog 2 (EZH2) could play a role in inflammation and a wide range of malignancies; however, the underlying mechanisms remain largely unaddressed. Microglial activation is a key process in the production and release of numerous pro-inflammatory mediators that play important roles in inflammation and neurodegeneration in the central nervous system...

article

Synergistic anti-tumor effects of bevacizumab and tumor targeted polymerized VEGF siRNA nanoparticles

Myung Goo Kim, Sung Duk Jo, Ji Young Yhee, Beom Suk Lee, more

Biochemical and Biophysical Research Communications > 2017 > 489 > 1 > 35-41

A variety of VEGF inhibitors have been reported to treat cancers by suppressing tumor angiogenesis. Bevacizumab, a monoclonal VEGF antibody, was the first FDA approved anti-angiogenic agent for cancer treatments. However, bevacizumab shows modest therapeutic efficiency and often cause resistant problem in significant populations of cancer patients. To solve these problem, we investigated the therapeutic...

article

FTY720 (fingolimod) regulates key target genes essential for inflammation in microglial cells as defined by high-resolution mRNA sequencing

Amitabh Das, Sarder Arifuzzaman, Sun Hwa Kim, Young Seek Lee, more

Neuropharmacology > 2017 > 119 > C > 1-14

Although microglial cells have an essential role in the host defense of the brain, the abnormal activation of microglia can lead to devastating outcomes, such as neuroinflammation and neurodegeneration. Emerging evidence indicates that FTY720 (fingolimod), an FDA-approved drug, has beneficial effects on brain cells in the central nervous system (CNS) and, more recently, immunosuppressive activities...

article

Multivalent Aptamer–RNA Conjugates for Simple and Efficient Delivery of Doxorubicin/siRNA into Multidrug‐Resistant Cells

Hyosook Jeong, Soo Hyeon Lee, Yeonju Hwang, Hyundong Yoo, more

Macromolecular Bioscience > 17 > 4 > n/a - n/a

Multivalent aptamer–siRNA conjugates containing multiple mucin‐1 aptamers and BCL2‐specific siRNA are synthesized, and doxorubicin, an anthracycline anticancer drug, is loaded into these conjugates through intercalation with nucleic acids. These doxorubicin‐incorporated multivalent aptamer–siRNA conjugates are transfected to mucin‐1 overexpressing MCF‐7 breast cancer cells and their multidrug‐resistant...

article

Preoperative and Postoperative Analysis of Serous Cystic Neoplasms and Mucinous Cystic Neoplasms; Diagnostic Accuracy and Clinical Applications

Jae Keun Park, Sun Hwa Kim, Namyoung Paik, Joo Kyung Park, more

Gastroenterology > 2017 > 152 > 5(S1) > S674

article

Polysaccharide-based Nanoparticles for Gene Delivery

Myung Sook Huh, Eun Jung Lee, Heebeom Koo, Ji Young Yhee, more

Topics in Current Chemistry > 2017 > 375 > 2 > 1-19

Nanoparticles based on nanotechnology and biotechnology have emerged as efficient carriers for various biopharmaceutical agents including proteins and genes. In particular, polysaccharides have attracted interest of many researchers in the drug delivery field due to their advantages such as biocompatibility, biodegradability, low toxicity, and ease of modification. A number of polysaccharides including...

article

Simultaneous regulation of apoptotic gene silencing and angiogenic gene expression for myocardial infarction therapy: Single-carrier delivery of SHP-1 siRNA and VEGF-expressing pDNA

Dongkyu Kim, Sook Hee Ku, Hyosuk Kim, Ji Hoon Jeong, more

Journal of Controlled Release > 2016 > 243 > C > 182-194

Gene therapy is aimed at selectively knocking up or knocking down the target genes involved in the development of diseases. In many human diseases, dysregulation of disease-associated genes is occurred concurrently: some genes are abnormally turned up and some are turned down. In the field of non-viral gene therapy, plasmid DNA (pDNA) and small interfering RNA (siRNA) are suggested as representative...

article

Reducible Polyethylenimine Nanoparticles for Efficient siRNA Delivery in Corneal Neovascularization Therapy

Hyounkoo Han, Sohee Son, Sejin Son, Namho Kim, more

Macromolecular Bioscience > 16 > 11 > 1583 - 1597

The aim of this study is to establish the safe and effective ocular delivery system of therapeutic small interfering RNA (siRNA) in corneal neovascularization therapy. The major hurdle present in siRNA‐based corneal neovascularization (CNV) therapy is severe cytotoxicity caused by repetitive drug treatment. A reducible branched polyethylenimine (rBPEI)‐based nanoparticle (NP) system is utilized as...

article

Macromol. Biosci. 11/2016

Hyounkoo Han, Sohee Son, Sejin Son, Namho Kim, more

Macromolecular Bioscience > 16 > 11 > 1547 - 1547

Front Cover: A reducible branched polyethylenimine (rBPEI)‐based nanoparticle (NP) system is introduced as a siRNA carrier to corneal neovascularization therapy. The rBPEI‐NPs are efficiently degraded into LMW BPEI inside the cytosol to facilitate a release of siRNA targeting NFkB. Eventually, a significant anti‐angiogensis effect without noticeable toxicity is shown. Further details can be found...

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INFONA - science communication portal

Search results for: Sun Hwa Kim

Light‐Triggered PROTAC Nanoassemblies for Photodynamic IDO Proteolysis in Cancer Immunotherapy (Adv. Mater. 38/2024)

Light‐Triggered PROTAC Nanoassemblies for Photodynamic IDO Proteolysis in Cancer Immunotherapy

Market potential and value‐added opportunities of cold‐hardy berries and small fruits in the Intermountain West, USA

Sustained Exosome‐Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and MiRNAs, and Sustained Release Formulation

Information Risk and Debtholders’ Mispricing by Considering Audit Quality*

Combination of bisacodyl suppository and 1 L polyethylene glycol plus ascorbic acid is a non‐inferior and comfortable regimen compared to 2 L polyethylene glycol plus ascorbic acid

Su1712 USEFULNESS OF BISACODYL SUPPOSITORY AGENT FOR VOLUME REDUCTION OF BOWEL PREPARATION AGENT

Gene expression signatures after ethanol exposure in differentiating embryoid bodies

Memory loss and decreased executive function are associated with limited functional capacity in patients with heart failure compared to patients with other medical conditions

Synergistic antitumor effects of combination treatment with metronomic doxorubicin and VEGF-targeting RNAi nanoparticles

Rolling circle transcription-based polymeric siRNA nanoparticles for tumor-targeted delivery

Selective inhibition of EZH2 by a small molecule inhibitor regulates microglial gene expression essential for inflammation

Synergistic anti-tumor effects of bevacizumab and tumor targeted polymerized VEGF siRNA nanoparticles

FTY720 (fingolimod) regulates key target genes essential for inflammation in microglial cells as defined by high-resolution mRNA sequencing

Multivalent Aptamer–RNA Conjugates for Simple and Efficient Delivery of Doxorubicin/siRNA into Multidrug‐Resistant Cells

Preoperative and Postoperative Analysis of Serous Cystic Neoplasms and Mucinous Cystic Neoplasms; Diagnostic Accuracy and Clinical Applications

Polysaccharide-based Nanoparticles for Gene Delivery

Simultaneous regulation of apoptotic gene silencing and angiogenic gene expression for myocardial infarction therapy: Single-carrier delivery of SHP-1 siRNA and VEGF-expressing pDNA

Reducible Polyethylenimine Nanoparticles for Efficient siRNA Delivery in Corneal Neovascularization Therapy

Macromol. Biosci. 11/2016

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