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The penta‐ethyl ester of diethylenetriamine pentaacetic acid (DTPA), a DTPA prodrug designated as C2E5 intended for transdermal delivery for radionuclide decorporation, was first screened with a prototype cream formulation and a hydrocarbon base ointment with C2E5 concentration ranging from 1% to 20%. C2E5 experienced rapid degradation in the cream matrix and C2E5 ointment formulation underwent phase...
Diethylenetriamine pentaacetic acid penta-ethyl ester, designated as C2E5, was successfully incorporated into a nonaqueous gel for transdermal delivery. The thermal and rheological properties of a formulation containing 40% C2E5, 20% ethyl cellulose, and 40% Miglyol 840® prepared using the solvent evaporation method demonstrated that the gel had acceptable content uniformity and flow properties. In vitro...
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