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Previously we found that exposure to electromagnetic pulse (EMP) induced an increase in blood–brain-barrier (BBB) permeability and the degradation of tight junction protein ZO-1 in rats. Matrix metalloproteinases (MMPs), in particular gelatinases (MMP-2 and MMP-9), play a key role in degradation of tight junction proteins, are known mediators of BBB compromise. We hypothesized that the degradation...
The aim of this study was to determine the role of protein kinase C signaling in electromagnetic pulse (EMP)-induced blood–brain barrier (BBB) permeability change in rats. The protein level of total PKC and two PKC isoforms (PKC-α, and PKC-β II) were determined in brain cerebral cortex microvessels by Western blot after exposing rats to EMP at 200kV/m for 200 pulses with 1Hz repetition rate. It was...
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