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New protein delivery systems are needed that efficiently encapsulate proteins and avoid formulation processes that affect protein structure and function. We have developed a protein delivery system termed disulfide-crosslinked polyion micelles (DCPMs), which consist of nanocomplexes formed by electrostatic self-assembly of a protein with a poly(ethylene glycol)-poly(l-lysine) block copolymer (PEG-PLL)...
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