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Tandem‐Peptidcyclisierung A. Friedler et al. stellen in ihrer Zuschrift auf S. 9604 ff. eine Tandemstrategie für die Festphasencyclisierung von Peptiden unter stark sauren Bedingungen vor. Der Prozess umfasst eine In‐situ‐Entschützung, gefolgt von der Cyclisierung und Peptidabspaltung mit Trifluoressigsäure.
We present a new approach for peptide cyclization during solid phase synthesis under highly acidic conditions. Our approach involves simultaneous in situ deprotection, cyclization and trifluoroacetic acid (TFA) cleavage of the peptide, which is achieved by forming an amide bond between a lysine side chain and a succinic acid linker at the peptide N‐terminus. The reaction proceeds via a highly active...
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