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Scaffolds functionalized with delivery systems for the release of growth factors is a robust strategy to enhance tissue regeneration. However, after implantation, macrophages infiltrate the scaffold, eventually initiating the degradation and clearance of the delivery systems. Herein, it is hypothesized that fully embedding the poly(d,l‐lactide‐co‐glycolide acid) microspheres (MS) in a highly structured...
Avoiding the clearance of drug delivery systems from 3D scaffolds is crucial to preserve the bioactivity of their therapeutic payload. This is accomplished on page 1479, by E. Tasciotti and co‐workers, through a “concealing” strategy: cloaking PLGA microspheres with the type I collagen matrix of a biomimetic scaffold, which enables the control of the production of inflammatory mediators.
The interaction of immune cells with biomaterials has been identified as a possible predictor of either the success or the failure of the implant. Among immune cells, macrophages have been found to contribute to both of these possible scenarios, based on their polarization profile. This proof-of-concept study aimed to investigate if it was possible to affect the response of macrophages to biomaterials,...
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