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Reestablishment of bladder function in patients with spinal cord injury (SCI) is a clinical priority. Our objectives were to determine whether SCI-localized inhibition of purinergic P2X7 receptors (P2X7R) improve bladder function by decreasing afferent signals mediated by urothelial P2X3R.Systemic inhibition of P2X7R may improve locomotion in rodent SCI models; however, beneficial effects on bladder...
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