Search results for: Manabu Abe

Items from 1 to 20 out of 130 results

article

Activity‐induced secretion of semaphorin 3A mediates learning

Aoi Jitsuki‐Takahashi, Susumu Jitsuki, Naoya Yamashita, Meiko Kawamura, more

European Journal of Neuroscience > 53 > 10 > 3279 - 3293

The semaphorin family is a well‐characterized family of secreted or membrane‐bound proteins that are involved in activity‐independent neurodevelopmental processes, such as axon guidance, cell migration, and immune functions. Although semaphorins have recently been demonstrated to regulate activity‐dependent synaptic scaling, their roles in Hebbian synaptic plasticity as well as learning and memory...

article

Heterogeneity of microglial proton channel in different brain regions and its relationship with aging

Takafumi Kawai, Keizo Takao, Sharmin Akter, Manabu Abe, more

Journal of Neurochemistry > 157 > 3 > 624 - 641

The properties of microglia largely differ depending on aging as well as on brain regions. However, there are few studies that investigated the functional importance of such heterogeneous properties of microglia at the molecular level. Voltage‐gated proton channel, Hv1/VSOP, could be one of the candidates which confers functional heterogeneity among microglia since it regulates brain oxidative stress...

article

Dysregulation of sphingolipid metabolic enzymes leads to high levels of sphingosine‐1‐phosphate and ceramide in human hepatocellular carcinoma

Kohei Miura, Masayuki Nagahashi, Pankaj Prasoon, Yuki Hirose, more

Hepatology Research > 51 > 5 > 614 - 626

Aim Sphingosine‐1‐phosphate (S1P) and ceramide are bioactive sphingolipids known to be important in regulating numerous processes involved in cancer progression. The aim of this study was to determine the absolute levels of sphingolipids in hepatocellular carcinoma (HCC) utilizing data obtained from surgical specimens. In addition, we explored the clinical significance of S1P in patients with HCC...

article

Chemistry of Tertiary Carbon Center in the Formation of Congested C−O Ether Bonds

Goki Hirata, Kentarou Takeuchi, Yusuke Shimoharai, Michinori Sumimoto, more

Angewandte Chemie > 133 > 8 > 4375 - 4380

Nucleophilic substitutions, including S_N1 and S_N2, are classical and reliable reactions, but a serious drawback is their intolerance for both bulky nucleophiles and chiral tertiary alkyl electrophiles for the synthesis of a chiral quaternary carbon center. An S_RN1 reaction via a radical species is another conventional method used to carry out substitution reactions of bulky nucleophiles and alkyl...

article

Innentitelbild: Chemistry of Tertiary Carbon Center in the Formation of Congested C−O Ether Bonds (Angew. Chem. 8/2021)

Goki Hirata, Kentarou Takeuchi, Yusuke Shimoharai, Michinori Sumimoto, more

Angewandte Chemie > 133 > 8 > 3870 - 3870

Eine stereospezifische nukleophile Substitution zwischen tertiären Alkylbromiden und tertiären Alkylalkoholen wird auf S. 4375 im Forschungsartikel von Toshiki Nokami, Takashi Koike, Manabu Abe, Eiji Shirakawa, Takashi Nishikata und Mitarbeitern beschrieben. Der eintretende Alkohol greift formal die C‐Br‐Bindung an, um eine retentive Substitution unter Bildung von tertiären Alkylethern einzugehen...

article

Chemistry of Tertiary Carbon Center in the Formation of Congested C−O Ether Bonds

Goki Hirata, Kentarou Takeuchi, Yusuke Shimoharai, Michinori Sumimoto, more

Angewandte Chemie International Edition > 60 > 8 > 4329 - 4334

article

Inside Cover: Chemistry of Tertiary Carbon Center in the Formation of Congested C−O Ether Bonds (Angew. Chem. Int. Ed. 8/2021)

Goki Hirata, Kentarou Takeuchi, Yusuke Shimoharai, Michinori Sumimoto, more

Angewandte Chemie International Edition > 60 > 8 > 3826 - 3826

A stereospecific nucleophilic substitution between tertiary alkyl bromides and tertiary alkyl alcohols is described in the Research Article on page 4329 by Toshiki Nokami, Takashi Koike, Manabu Abe, Eiji Shirakawa, Takashi Nishikata, and co‐workers. The entering alcohol formally attacks the C−Br bond to undergo a retentive substitution with formation of tertiary alkyl ethers.

article

Kv11 (ether‐à‐go‐go‐related gene) voltage‐dependent K⁺ channels promote resonance and oscillation of subthreshold membrane potentials

Toshinori Matsuoka, Miwako Yamasaki, Manabu Abe, Yukiko Matsuda, more

The Journal of Physiology > 599 > 2 > 547 - 569

Key points Some ion channels are known to behave as inductors and make up the parallel resonant circuit in the plasma membrane of neurons, which enables neurons to respond to current inputs with a specific frequency (so‐called ‘resonant properties’). Here, we report that heterologous expression of mouse Kv11 voltage‐dependent K⁺ channels generate resonance and oscillation at depolarized membrane...

article

Disruption of dystonin in Schwann cells results in late‐onset neuropathy and sensory ataxia

Masao Horie, Nozomu Yoshioka, Satoshi Kusumi, Hiromi Sano, more

Glia > 68 > 11 > 2330 - 2344

Dystonin (Dst) is a causative gene for Dystonia musculorum (dt) mice, which is an inherited disorder exhibiting dystonia‐like movement and ataxia with sensory degeneration. Dst is expressed in a variety of tissues, including the central nervous system and the peripheral nervous system (PNS), muscles, and skin. However, the Dst‐expressing cell type(s) for dt phenotypes have not been well characterized...

article

Expression mapping, quantification, and complex formation of GluD1 and GluD2 glutamate receptors in adult mouse brain

Chihiro Nakamoto, Kohtarou Konno, Taisuke Miyazaki, Ena Nakatsukasa, more

Journal of Comparative Neurology > 528 > 6 > 1003 - 1027

In the cerebellum, GluD2 is exclusively expressed in Purkinje cells, where it regulates synapse formation and regeneration, synaptic plasticity, and motor learning. Delayed cognitive development in humans with GluD2 gene mutations suggests extracerebellar functions of GluD2. However, extracerebellar expression of GluD2 and its relationship with that of GluD1 are poorly understood. GluD2 mRNA and protein...

article

Efficient Generation and Synthetic Applications of Alkyl‐Substituted Siloxycarbenes: Suppression of Norrish‐Type Fragmentations of Alkanoylsilanes by Triplet Energy Transfer

Kento Ishida, Hokuto Yamazaki, Chihiro Hagiwara, Manabu Abe, more

Chemistry – A European Journal > 26 > 6 > 1249 - 1253

Acylsilanes have been known to undergo isomerization to siloxycarbenes under photoirradiation and the thus generated carbenes can be utilized for various synthetic reactions. But this carbene formation is not necessarily efficient with some alkanoylsilanes because Norrish‐type fragmentations compete, which limit the synthetic utility of alkanoylsilanes as carbene precursors. In this study, generation...

article

Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1−Akt signaling pathway

Kohei Nishino, Seiji Watanabe, Jin Shijie, Yuri Murata, more

Acta Neuropathologica Communications > 2019 > 7 > 1 > 1-15

Intracellular mislocalization of TAR DNA-binding protein 43 (TDP-43), a nuclear DNA/RNA-binding protein involved in RNA metabolism, is a pathological hallmark of amyotrophic lateral sclerosis (ALS). Although the aggregation-prone, TDP-43 C-terminal domain is widely considered as a key component of TDP-43 pathology in ALS, recent studies including ours suggest that TDP-43 N-terminal fragments (TDP-∆C)...

article

The Effect of Viscosity on the Diffusion and Termination Reaction of Organic Radical Pairs

Xiaopei Li, Tasuku Ogihara, Manabu Abe, Yasuyuki Nakamura, more

Chemistry – A European Journal > 25 > 42 > 9846 - 9850

The effect of viscosity on the diffusion efficiency (F_dif) of an organic radical pair in a solvent cage and the termination mechanism, that is, the selectivity of disproportionation (Disp) and combination (Comb) of the geminated caged radical pair and the diffused radicals encountered, were investigated quantitatively by following the photolysis of dimethyl 2,2′‐azobis(2‐methylpropionate) (V‐601)...

article

Mechanical regulation of oligodendrocyte morphology and maturation by the mechanosensor p130Cas

Takeshi Shimizu, Yasuyuki Osanai, Kenji F. Tanaka, Truc Quynh Thai, more

Journal of Neurochemistry > 150 > 2 > 158 - 172

Oligodendrocytes (OLs) are myelinating cells of the central nervous system. Recent studies have shown that mechanical factors influence various cell properties. Mechanical stimulation can be transduced into intracellular biochemical signals through mechanosensors, such as integrin, p130Cas, talin and vinculin. However, the molecular mechanisms underlying the mechanical regulation of OLs by mechanosensors...

article

Cathepsin C modulates myelin oligodendrocyte glycoprotein‐induced experimental autoimmune encephalomyelitis

Wilaiwan Wisessmith Durose, Takahiro Shimizu, JiaYi Li, Manabu Abe, more

Journal of Neurochemistry > 148 > 3 > 413 - 425

Multiple sclerosis (MS) is an autoimmune disease characterized by immune‐mediated inflammation, which attacks the myelin sheath. MS pursues a relapsing and remitting course with varying intervals between symptoms. The main clinical pathological features include inflammation, myelin sheath destruction and plaque formation in the central nervous system (CNS). We previously reported that cystatin F...

article

Deletion of exons encoding carboxypeptidase domain of Nna1 results in Purkinje cell degeneration (pcd) phenotype

Li Zhou, M. Ibrahim Hossain, Maya Yamazaki, Manabu Abe, more

Journal of Neurochemistry > 147 > 4 > 557 - 572

Purkinje cell degeneration (pcd) was first identified in a spontaneous mouse mutant showing cerebellar ataxia. In addition to cerebellar Purkinje cells (PCs), retinal photoreceptors, mitral cells in the olfactory bulb, and a discrete subpopulation of thalamic neurons also degenerate in the mutant brains. The gene responsible for the pcd mutant is Nna1, also known as ATP/GTP binding protein 1 or cytosolic carboxypeptidase‐like 1,...

article

Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery

Tayo Katano, Keizo Takao, Manabu Abe, Maya Yamazaki, more

Molecular Brain > 2018 > 11 > 1 > 1-20

Calcium/calmodulin-dependent serine protein kinase (CASK)-interacting protein 1 (Caskin1) is a direct binding partner of the synaptic adaptor protein CASK. Because Caskin1 forms homo-multimers and binds not only CASK but also other neuronal proteins in vitro, it is anticipated to have neural functions; but its exact role in mammals remains unclear. Previously, we showed that the concentration of Caskin1...

article

Extremely Long Lived Localized Singlet Diradicals in a Macrocyclic Structure: A Case Study on the Stretch Effect

Yuta Harada, Zhe Wang, Shunsuke Kumashiro, Sayaka Hatano, more

Chemistry – A European Journal > 24 > 55 > 14808 - 14815

Localized singlet diradicals have attracted much attention, not only in the field of bond‐homolysis chemistry, but also in nonlinear optical materials. In this study, an extremely long lived localized singlet diradical was obtained by using a new molecular design strategy in which it is kinetically stabilized by means of a macrocycle that increases the molecular strain of the corresponding σ‐bonded...

article

CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration

Natsumi Ageta-Ishihara, Kohtarou Konno, Maya Yamazaki, Manabu Abe, more

Neurochemistry International > 2018 > 119 > C > 190-198

Configuration of tripartite synapses, comprising the pre-, post-, and peri-synaptic components (axon terminal or bouton, dendritic spine, and astroglial terminal process), is a critical determinant of neurotransmitter kinetics and hence synaptic transmission. However, little is known about molecular basis for the regulation of tripartite synapse morphology. Previous studies showed that CDC42EP4, an...

article

CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse

Wei Dong, Tamara Radulovic, R. Oliver Goral, Connon Thomas, more

Cell Reports > 2018 > 24 > 2 > 284-293.e6

In the presynaptic terminal, the magnitude and location of Ca²⁺ entry through voltage-gated Ca²⁺ channels (VGCCs) regulate the efficacy of neurotransmitter release. However, how presynaptic active zone proteins control mammalian VGCC levels and organization is unclear. To address this, we deleted the CAST/ELKS protein family at the calyx of Held, a Ca_V2.1 channel-exclusive presynaptic terminal. We...

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INFONA - science communication portal

Search results for: Manabu Abe

Activity‐induced secretion of semaphorin 3A mediates learning

Heterogeneity of microglial proton channel in different brain regions and its relationship with aging

Dysregulation of sphingolipid metabolic enzymes leads to high levels of sphingosine‐1‐phosphate and ceramide in human hepatocellular carcinoma

Chemistry of Tertiary Carbon Center in the Formation of Congested C−O Ether Bonds

Innentitelbild: Chemistry of Tertiary Carbon Center in the Formation of Congested C−O Ether Bonds (Angew. Chem. 8/2021)

Chemistry of Tertiary Carbon Center in the Formation of Congested C−O Ether Bonds

Inside Cover: Chemistry of Tertiary Carbon Center in the Formation of Congested C−O Ether Bonds (Angew. Chem. Int. Ed. 8/2021)

Kv11 (ether‐à‐go‐go‐related gene) voltage‐dependent K⁺ channels promote resonance and oscillation of subthreshold membrane potentials

Disruption of dystonin in Schwann cells results in late‐onset neuropathy and sensory ataxia

Expression mapping, quantification, and complex formation of GluD1 and GluD2 glutamate receptors in adult mouse brain

Efficient Generation and Synthetic Applications of Alkyl‐Substituted Siloxycarbenes: Suppression of Norrish‐Type Fragmentations of Alkanoylsilanes by Triplet Energy Transfer

Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1−Akt signaling pathway

The Effect of Viscosity on the Diffusion and Termination Reaction of Organic Radical Pairs

Mechanical regulation of oligodendrocyte morphology and maturation by the mechanosensor p130Cas

Cathepsin C modulates myelin oligodendrocyte glycoprotein‐induced experimental autoimmune encephalomyelitis

Deletion of exons encoding carboxypeptidase domain of Nna1 results in Purkinje cell degeneration (pcd) phenotype

Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery

Extremely Long Lived Localized Singlet Diradicals in a Macrocyclic Structure: A Case Study on the Stretch Effect

CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration

CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse

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