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A new in vitro microfluidic platform (integrated insert dynamic microfluidic platform, IIDMP) allowing the co‐culture of intestinal Caco‐2 TC7 cells and of human primary hepatocytes was used to test the absorption and first‐pass metabolism of two drugs: phenacetin and omeprazole. The metabolism of these drugs by CYP1A2, CYP2C19 and CYP3A4 was evaluated by the calculation of bioavailabilities and of...
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