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Campath-1H, the first humanized therapeutic antibody, recognizes the CDw52 antigen expressed on human lymphocytes and monocytes. CDw52 is a good target for antibody-mediated killing and has therefore been used in lymphoma therapy and for immunosuppression. Humanization was carried out by grafting the CDR loops of the rat antibody (Campath-1G) onto human framework backbone of crystallographically...
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