Search results for: Xiaodi Su

Items from 1 to 20 out of 71 results

article

Greatly Enhanced Resonant Exciton‐Trion Conversion in Electrically Modulated Atomically Thin WS₂ at Room Temperature

Zeng Wang, Matej Sebek, Xinan Liang, Ahmed Elbanna, more

Advanced Materials > 35 > 33 > n/a - n/a

Excitonic resonance in atomically thin semiconductors offers a favorite platform to study 2D nanophotonics in both classical and quantum regimes and promises potentials for highly tunable and ultra‐compact optical devices. The understanding of charge density dependent exciton‐trion conversion is the key for revealing the underlaying physics of optical tunability. Nevertheless, the insufficient and...

article

Amplification-free and direct fluorometric determination of telomerase activity in cell lysates using chimeric DNA-templated silver nanoclusters

Shi Ting Lee, Ruman Rahman, Kasturi Muthoosamy, Nur Aliana Hidayah Mohamed, more

Microchimica Acta > 2019 > 186 > 2 > 1-10

A fluorogenic probe has been developed for determination of telomerase activity using chimeric DNA-templated silver nanoclusters (AgNCs). The formation of AgNCs was investigated before (route A) and after (route B) telomerase elongation reaction. Both routes caused selective quenching of the yellow emission of the AgNCs (best measured at excitation/emission wavelength of 470/557 nm) in telomerase-positive...

article

Fluorescence sensing of protein-DNA interactions using conjugated polymers and graphene oxide

Roger M. Pallares, Laura Sutarlie, Nguyễn T.K. Thanh, Xiaodi Su

Sensors and Actuators B: Chemical > 2018 > 271 > C > 97-103

Protein-DNA binding, particularly transcription factor-DNA binding, is one of the main molecular interactions involved in gene regulation. These interactions are sequence-specific, play a key role in many fundamental biological processes, and are deregulated in the pathogenesis of several diseases. In this study, a robust analytical bioassay to characterize protein-DNA binding was built by combining...

article

Nanomaterials‐based biosensors for detection of microorganisms and microbial toxins

Laura Sutarlie, Sian Yang Ow, Xiaodi Su

Biotechnology Journal > 12 > 4 > n/a - n/a

Detection of microorganisms and microbial toxins is important for health and safety. Due to their unique physical and chemical properties, nanomaterials have been extensively used to develop biosensors for rapid detection of microorganisms with microbial cells and toxins as target analytes. In this paper, the design principles of nanomaterials‐based biosensors for four selected analyte categories...

article

Identification of lysine K18 acetylation on histone H3 peptide using gold nanoparticles’ aggregation behaviour

Ning Li, Laura Sutarlie, Qiao Jing Lew, Sheng-Hao Chao, more

Amino Acids > 2016 > 48 > 4 > 1023-1031

Acetylation of histones, the major protein component of eukaryotic chromosomes, contributes to the epigenetic regulation of gene expression and is also involved in cancer development. A recent study revealed the correlation between tumour formation and acetylation level of lysine K18 on histone H3. In this study, we developed two colorimetric in vitro assays using gold nanoparticles (AuNPs) for identification...

article

Serum Albumin Binding Inhibits Nuclear Uptake of Luminescent Metal‐Complex‐Based DNA Imaging Probes

Ashley Wragg, Martin R. Gill, Luke McKenzie, Caroline Glover, more

Chemistry – A European Journal > 21 > 33 > 11865 - 11871

The DNA binding and cellular localization properties of a new luminescent heterobimetallic Ir^IIIRu^II tetrapyridophenazine complex are reported. Surprisingly, in standard cell media, in which its tetracationic, isostructural Ru^IIRu^II analogue is localized in the nucleus, the new tricationic complex is poorly taken up by live cells and demonstrates no nuclear staining. Consequent cell‐free studies reveal...

article

A Nanoplasmonic‐Fluorescent Ruler for Detection of Site‐Specific Protein Binding to Composite DNA of Multiple Sites

Steven Lukman, Laura Sutarlie, Ning Li, Xiaodi Su

Particle & Particle Systems Characterization > 31 > 12 > 1281 - 1290

A gold or silver nanoparticles (AuNPs and AgNPs)‐supported fluorescent intercalator displacement (FID) assay, termed nanoplasmonic‐fluorescent ruler, for site‐specific detection of protein binding to composite DNA of multiple sites is constructed. A 20 nm, 100 nm AuNPs, or 80 nm AgNPs is introduced to one end of double‐stranded DNA (dsDNA). The dsDNA–AuNPs conjugates are saturated with a DNA intercalator,...

article

Tuning the Cellular Uptake Properties of Luminescent Heterobimetallic Iridium(III)–Ruthenium(II) DNA Imaging Probes

Ashley Wragg, Martin R. Gill, David Turton, Harry Adams, more

Chemistry – A European Journal > 20 > 43 > 14004 - 14011

The synthesis of two new luminescent dinuclear Ir^III–Ru^II complexes containing tetrapyrido[3,2‐a:2′,3′‐c:3′′,2′′‐h:2′′′,3′′′‐j]phenazine (tpphz) as the bridging ligand is reported. Unlike many other complexes incorporating cyclometalated Ir^III moieties, these complexes display good water solubility, allowing the first cell‐based study on Ir^III–Ru^II bioprobes to be carried out. Photophysical studies...

article

Spacer effect of cooperative binding of estrogen receptor α and specificity protein 1 to composite DNA: A surface plasmon resonance study

Hong Yan Song, Xiaodi Su

Sensors & Actuators: B. Chemical > 2014 > 195 > Complete > 635-642

Estrogen receptor α (ERα) and specificity protein 1 (Sp1) are transcriptional factors (TF) that are involved in regulating progesterone receptor (PR) gene expression through cooperative interactions with DNA. In this study, we for the first time studied the cooperative interaction of recombinant proteins Sp1 and ERα with composite DNA of +571 ERE/Sp1 site in promoter A from the human PR gene, using...

article

Studying forkhead box protein A1–DNA interaction and ligand inhibition using gold nanoparticles, electrophoretic mobility shift assay, and fluorescence anisotropy

Khin Moh Moh Aung, Siu Yee New, Shuzhen Hong, Laura Sutarlie, more

Analytical Biochemistry > 2014 > 448 > C > 95-104

Forkhead box protein 1 (FoxA1) is a member of the forkhead family of winged helix transcription factors that plays pivotal roles in the development and differentiation of multiple organs and in the regulation of estrogen-stimulated genes. Conventional analytical methods—electrophoretic mobility shift assay (EMSA) and fluorescence anisotropy (FA)—as well as a gold nanoparticles (AuNPs)-based assay...

article

End-on Covalent Antibody Immobilization on Dual Polarization Interferometry Sensor Chip for Enhanced Immuno-sensing

Hong Yan Song, Jonathan Hobley, Xiaodi Su, Xiaodong Zhou

Plasmonics > 2014 > 9 > 4 > 851-858

End-on immobilization of antibody is an important technology to greatly improve the sensitivity of immuno-sensing. The end-on, or constant fragment (Fc) site-specifically oriented antibodies expose more active antigen binding sites (Fab) and tend to capture more analytes from the solution. In this study, dual polarization interferometry (DPI), which is the only available equipment that can concurrently...

article

Studying Protein–DNA Complexes Using Gold Nanoparticles by Exploiting Particle Aggregation, Refractive Index Change, and Fluorescence Quenching and Enhancement Principles

Laura Sutarlie, Khin Moh Moh Aung, Michelle Gek Liang Lim, Steven Lukman, more

Plasmonics > 2014 > 9 > 4 > 753-763

Gold nanoparticles (AuNPs) have a unique optical phenomena termed localized surface plasmon resonance that is determined by particle shape, size, interparticle distance (or aggregation status), and local refractive index. AuNPs can also modulate fluorescence emission of proximal fluorophores under the Förster resonance energy transfer and/or nanoparticle surface energy transfer mechanisms. In this...

article

Antimicrobial functionalization of silicone surfaces with engineered short peptides having broad spectrum antimicrobial and salt-resistant properties

Xiang Li, Peng Li, Rathi Saravanan, Anindya Basu, more

Acta Biomaterialia > 2014 > 10 > 1 > 258-266

Catheter-associated urinary tract infections (CAUTIs) are often preceded by pathogen colonization on catheter surfaces and are a major health threat facing hospitals worldwide. Antimicrobial peptides (AMPs) are a class of new antibiotics that hold promise in curbing CAUTIs caused by antibiotic-resistant pathogens. This study aims to systematically evaluate the feasibility of immobilizing two newly...

article

Plasmonic metal nanostructure array by glancing angle deposition for biosensing application

Nan Zhang, Xiaodi Su, Paul Free, Xiaodong Zhou, more

Sensors & Actuators: B. Chemical > 2013 > 183 > Complete > 310-318

This paper investigates the application of gold nanostructure array fabricated on a layer of closely packed polystyrene (PS) nanospheres as a plasmonic chemical or biological sensor. The sensing chip was fabricated by first functionalizing a layer of closely packed PS nanospheres as a colloidal template, and then depositing the gold at an oblique angle, where the nanospheres shaded each other and...

article

Study sequence rules of estrogen receptor α–DNA interactions using dual polarization interferometry and computational modeling

Hong Yan Song, Wenjie Sun, Shyam Prabhakar, Khin Moh Moh Aung, more

Analytical Biochemistry > 2013 > 433 > 2 > 121-128

Estrogen receptor α (ERα) is a ligand-activated transcription factor. In a classical model, ERα regulates gene expression by binding to DNA sequences called estrogen response elements (EREs). A perfect ERE contains a palindromic consensus sequence of 5′-GGTCAnnnTGACC-3′. A slight variation in ERE sequence alters ERα binding affinity and, thus, the gene transcription activity. In this study, all possible...

article

Designer tridentate mucin 1 aptamer for targeted drug delivery

Lihan Tan, Koon Gee Neoh, En‐Tang Kang, Woo‐Seok Choe, more

Journal of Pharmaceutical Sciences > 101 > 5 > 1672 - 1677

A single‐stranded DNA aptamer (APT) capable of targeting mucin 1 (MUC1) extracellular protein was modified to increase its drug delivery specificity toward MUC1 overexpressing cancer cell line, MCF7. The active targeting region of APT was truncated and variable repeats (one, two, or three) of this sequence were synthesized. An aptamer formed from three repeats of this active targeting region (L3)...

article

Affinity analysis of DNA aptamer–peptide interactions using gold nanoparticles

Lihan Tan, Koon Gee Neoh, En-Tang Kang, Woo-Seok Choe, more

Analytical Biochemistry > 2012 > 421 > 2 > 725-731

Gold nanoparticles (AuNPs) were used as colorimetric probe and fluorescence quencher for affinity analysis of DNA aptamers toward their target mucin 1 (MUC1) peptide. Single-stranded DNA (ssDNA) aptamer-coated AuNPs showed increased stability (i.e., more resistant to aggregation induced by NaCl) in the presence of their target peptide due to the increase in steric protection conferred by the ssDNA–peptide...

article

PEGylated Anti‐MUC1 Aptamer‐Doxorubicin Complex for Targeted Drug Delivery to MCF7 Breast Cancer Cells

Lihan Tan, Koon Gee Neoh, En‐Tang Kang, Woo Seok Choe, more

Macromolecular Bioscience > 11 > 10 > 1331 - 1335

Targeted drug delivery is especially important in cancer treatment as many anti‐cancer drugs are non‐specific and highly toxic to both cancer and normal cells. The targeted drug delivery of DOX to the MUC1‐expressing breast cancer cell line (MCF7) was obtained using APT as a carrier. Modification of the APT‐DOX complex by PEG increases the survivability of the macrophage control (RAW 264.7) by about...

article

Study of Single-Stranded DNA Binding Protein–Nucleic Acids Interactions using Unmodified Gold Nanoparticles and Its Application for Detection of Single Nucleotide Polymorphisms

Yen Nee Tan, Kwai Han Lee, Xiaodi Su

Analytical Chemistry > 2011 > 83 > 11 > 4251 - 4257

article

Surface plasmon resonance study of PNA interactions with double-stranded DNA

Cheeraporn Ananthanawat, Voravee P. Hoven, Tirayut Vilaivan, Xiaodi Su

Biosensors and Bioelectronics > 2011 > 26 > 5 > 1918-1923

Peptide nucleic acid (PNA) is a well known DNA analogue bearing a N-(2-aminoethyl)glycine backbone (aegPNA). This molecule is able to not only form a duplex with single stranded (ss) nucleic acids but also higher-order (i.e., three- and four-stranded) complexes with double-stranded (ds) DNA in a sequence specific manner. Here, the application of surface plasmon resonance (SPR) to study the binding...

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INFONA - science communication portal

Search results for: Xiaodi Su

Greatly Enhanced Resonant Exciton‐Trion Conversion in Electrically Modulated Atomically Thin WS₂ at Room Temperature

Amplification-free and direct fluorometric determination of telomerase activity in cell lysates using chimeric DNA-templated silver nanoclusters

Fluorescence sensing of protein-DNA interactions using conjugated polymers and graphene oxide

Nanomaterials‐based biosensors for detection of microorganisms and microbial toxins

Identification of lysine K18 acetylation on histone H3 peptide using gold nanoparticles’ aggregation behaviour

Serum Albumin Binding Inhibits Nuclear Uptake of Luminescent Metal‐Complex‐Based DNA Imaging Probes

A Nanoplasmonic‐Fluorescent Ruler for Detection of Site‐Specific Protein Binding to Composite DNA of Multiple Sites

Tuning the Cellular Uptake Properties of Luminescent Heterobimetallic Iridium(III)–Ruthenium(II) DNA Imaging Probes

Spacer effect of cooperative binding of estrogen receptor α and specificity protein 1 to composite DNA: A surface plasmon resonance study

Studying forkhead box protein A1–DNA interaction and ligand inhibition using gold nanoparticles, electrophoretic mobility shift assay, and fluorescence anisotropy

End-on Covalent Antibody Immobilization on Dual Polarization Interferometry Sensor Chip for Enhanced Immuno-sensing

Studying Protein–DNA Complexes Using Gold Nanoparticles by Exploiting Particle Aggregation, Refractive Index Change, and Fluorescence Quenching and Enhancement Principles

Antimicrobial functionalization of silicone surfaces with engineered short peptides having broad spectrum antimicrobial and salt-resistant properties

Plasmonic metal nanostructure array by glancing angle deposition for biosensing application

Study sequence rules of estrogen receptor α–DNA interactions using dual polarization interferometry and computational modeling

Designer tridentate mucin 1 aptamer for targeted drug delivery

Affinity analysis of DNA aptamer–peptide interactions using gold nanoparticles

PEGylated Anti‐MUC1 Aptamer‐Doxorubicin Complex for Targeted Drug Delivery to MCF7 Breast Cancer Cells

Study of Single-Stranded DNA Binding Protein–Nucleic Acids Interactions using Unmodified Gold Nanoparticles and Its Application for Detection of Single Nucleotide Polymorphisms

Surface plasmon resonance study of PNA interactions with double-stranded DNA

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