Search results for: Elaine Holmes

Items from 1 to 20 out of 171 results

article

Implementation of pure shift ¹H NMR in metabolic phenotyping for structural information recovery of biofluid metabolites with complex spin systems

Jose Ivan Serrano‐Contreras, John C. Lindon, Gary Frost, Elaine Holmes, more

NMR spectroscopy is a mainstay of metabolic profiling approaches to investigation of physiological and pathological processes. The one‐dimensional proton pulse sequences typically used in phenotyping large numbers of samples generate spectra that are rich in information but where metabolite identification is often compromised by peak overlap. Recently developed pure shift (PS) NMR spectroscopy, where...

article

Odd Chain Fatty Acids Are Not Robust Biomarkers for Dietary Intake of Fiber

Yiwei Wu, Joram M. Posma, Elaine Holmes, Gary Frost, more

Molecular Nutrition & Food Research > 65 > 22 > n/a - n/a

Scope Prior investigation has suggested a positive association between increased colonic propionate production and circulating odd‐chain fatty acids (OCFAs; pentadecanoic acid [C15:0], heptadecanoic acid [C17:0]). As the major source of propionate in humans is the microbial fermentation of dietary fiber, OCFAs have been proposed as candidate biomarkers of dietary fiber. The objective of this study...

article

Enhanced Microbial Bile Acid Deconjugation and Impaired Ileal Uptake in Pregnancy Repress Intestinal Regulation of Bile Acid Synthesis

Caroline Ovadia, Alvaro Perdones‐Montero, Konstantina Spagou, Ann Smith, more

Hepatology > 70 > 1 > 276 - 293

Pregnancy is associated with progressive hypercholanemia, hypercholesterolemia, and hypertriglyceridemia, which can result in metabolic disease in susceptible women. Gut signals modify hepatic homeostatic pathways, linking intestinal content to metabolic activity. We sought to identify whether enteric endocrine signals contribute to raised serum bile acids observed in human and murine pregnancies,...

article

Autotaxin, bile acid profile and effect of ileal bile acid transporter inhibition in primary biliary cholangitis patients with pruritus

Vinod S. Hegade, Alexandros Pechlivanis, Julie A. K. McDonald, Douglas Rees, more

Liver International > 39 > 5 > 967 - 975

Background and Aims Pruritus is a common symptom in patients with primary biliary cholangitis (PBC) for which ileal bile acid transporter (IBAT) inhibition is emerging as a potential therapy. We explored the serum metabonome and gut microbiota profile in PBC patients with pruritus and investigated the effect of GSK2330672, an IBAT inhibitor. Methods We studied fasting serum bile acids (BAs), autotaxin...

article

The effects of kisspeptin on β‐cell function, serum metabolites and appetite in humans

Chioma Izzi‐Engbeaya, Alexander N. Comninos, Sophie A. Clarke, Anne Jomard, more

Diabetes, Obesity and Metabolism > 20 > 12 > 2800 - 2810

Aims To investigate the effect of kisspeptin on glucose‐stimulated insulin secretion and appetite in humans. Materials and methods In 15 healthy men (age: 25.2 ± 1.1 years; BMI: 22.3 ± 0.5 kg m⁻²), we compared the effects of 1 nmol kg⁻¹ h⁻¹ kisspeptin versus vehicle administration on glucose‐stimulated insulin secretion, metabolites, gut hormones, appetite and food intake. In addition, we assessed...

article

PC232. Metabolic Profiling of High-Risk Carotid Atherosclerosis

Mahim Qureshi, Manuja Kaluarachchi, Panagiotis Vorkas, Elaine Holmes, more

Journal of Vascular Surgery > 2018 > 67 > 6 > e236

article

Improved physiology and metabolic flux after Roux-en-Y gastric bypass is associated with temporal changes in the circulating microRNAome: a longitudinal study in humans

Abdullah Alkandari, Hutan Ashrafian, Thozhukat Sathyapalan, Peter Sedman, more

BMC Obesity > 2018 > 5 > 1 > 1-11

Background The global pandemic of obesity and the metabolic syndrome are leading causes of mortality and morbidity. Bariatric surgery leads to sustained weight loss and improves obesity-associated morbidity including remission of type 2 diabetes. MicroRNAs are small, endogenous RNAs that regulate gene expression post-transcriptionally, controlling most of the human transcriptome and contributing to...

article

The C6H6 NMR repository: An integral solution to control the flow of your data from the magnet to the public

Luc Patiny, Michaël Zasso, Daniel Kostro, Andrés Bernal, more

Magnetic Resonance in Chemistry > 56 > 6 > 520 - 528

NMR is a mature technique that is well established and adopted in a wide range of research facilities from laboratories to hospitals. This accounts for large amounts of valuable experimental data that may be readily exported into a standard and open format. Yet the publication of these data faces an important issue: Raw data are not made available; instead, the information is slimed down into a string...

article

24 - A Novel Route to Controlling Clostridioides Difficile Growth via Short Chain Fatty Acid and Bile Acid Modulation

Julie A. McDonald, Benjamin H. Mullish, Alexandros Pechlivanis, Jia V. Li, more

Gastroenterology > 2018 > 154 > 6(S1) > S-8

article

Deep Vein Thrombosis Exhibits Characteristic Serum and Vein Wall Metabolic Phenotypes in the Inferior Vena Cava Ligation Mouse Model

Yeji Sung, Konstantina Spagou, Marina Kafeza, Michael Kyriakides, more

European Journal of Vascular and Endovascular Surgery > 2018 > 55 > 5 > 703-713

Deep vein thrombosis (DVT) is a major health problem, responsible for significant morbidity and mortality. The identification of a simple and effective diagnostic biomarker of DVT remains a challenge. Metabolomics have recently emerged as a new powerful scientific tool to characterise metabolic phenotypes of complex diseases and investigate small molecules in biofluids. The aim of the study was to...

article

126 - South Asian Ethnicity Drives Differences in Microbial and Metabolic Profiling in a Newly Diagnosed Ulcerative Colitis Cohort

Ravi Misra, Magali Sarafian, Alexandros Pechlivanis, Claire Boulange, more

Gastroenterology > 2018 > 154 > 6(S1) > S-33-S-34

article

Mo1945 - Effect of Bowel Purgatives on Urinary Metabolic Profiling Associated with the Faecal Microbiome

Sam T. Powles, Lucy C. Hicks, Leo W. Chong, James L. Alexander, more

Gastroenterology > 2018 > 154 > 6(S1) > S-860

article

CHANGES IN METABONOMIC PROFILE DURING PEANUT-INDUCED ANAPHYLAXIS AND CORRELATION WITH SYMPTOM

Paul J. Turner, Monica Ruiz Garcia, Isabel J. Skypala, Stephen R. Durham, more

Journal of Allergy and Clinical Immunology > 2018 > 141 > 2(S) > AB85

article

Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin

Richard G. Brown, Julian R. Marchesi, Yun S. Lee, Ann Smith, more

BMC Medicine > 2018 > 16 > 1 > 1-15

Background Preterm prelabour rupture of the fetal membranes (PPROM) precedes 30% of preterm births and is a risk factor for early onset neonatal sepsis. As PPROM is strongly associated with ascending vaginal infection, prophylactic antibiotics are widely used. The evolution of vaginal microbiota compositions associated with PPROM and the impact of antibiotics on bacterial compositions are unknown...

article

Rifaximin in non‐alcoholic steatohepatitis: An open‐label pilot study

Jeremy F.L. Cobbold, Stephen Atkinson, Julian R. Marchesi, Ann Smith, more

Hepatology Research > 48 > 1 > 69 - 77

Aim Gut microbial dysbiosis is implicated in the pathogenesis of non‐alcoholic steatohepatitis (NASH). We investigated downstream effects of gut microbiota modulation on markers of hepatic inflammation, steatosis, and hepatic and peripheral insulin sensitivity in patients with NASH using rifaximin therapy. Methods Patients with biopsy‐proven NASH and elevated aminotransferase values were included...

article

DISCOVERY AND VALIDATION OF MULTIMODAL BIOMARKER SIGNATURES RELATING TO ALZHEIMER'S DISEASE PATHOLOGY AND PROGRESSION

Sarah Westwood, Abdul Hye, Alberto Lleó, Alejo J. Nevado-Holgado, more

Alzheimer's & Dementia > 2017 > 13 > 7(S) > P174-P175

article

The Plasma and Serum Metabotyping of Hepatocellular Carcinoma in a Nigerian and Egyptian Cohort using Proton Nuclear Magnetic Resonance Spectroscopy

Mohamed I.F. Shariff, Jin Un Kim, Nimzing G. Ladep, Asmaa I. Gomaa, more

Journal of Clinical and Experimental Hepatology > 2017 > 7 > 2 > 83-92

Previous studies have observed disturbances in the ¹H nuclear magnetic resonance (NMR) blood spectral profiles in malignancy. No study has metabotyped serum or plasma of hepatocellular carcinoma (HCC) patients from two diverse populations. We aimed to delineate the HCC patient metabotype from Nigeria (mostly hepatitis B virus infected) and Egypt (mostly hepatitis C virus infected) to explore lipid...

article

Longitudinal analysis of serum oxylipin profile as a novel descriptor of the inflammatory response to surgery

Arnaud M. Wolfer, Alasdair J. Scott, Claudia Rueb, Mathieu Gaudin, more

Journal of Translational Medicine > 2017 > 15 > 1 > 1-11

Background Oxylipins are potent lipid mediators demonstrated to initiate and regulate inflammation yet little is known regarding their involvement in the response to surgical trauma. As key modulators of the inflammatory response, oxylipins have the potential to provide novel insights into the physiological response to surgery and the pathophysiology of post-operative complications. We aimed to investigate...

article

Metabolic Profiling in Patients with Pneumonia on Intensive Care

David Antcliffe, Beatriz Jiménez, Kirill Veselkov, Elaine Holmes, more

EBioMedicine > 2017 > 18 > Complete > 244-253

Clinical features and investigations lack predictive value when diagnosing pneumonia, especially when patients are ventilated and when patients develop ventilator associated pneumonia (VAP). New tools to aid diagnosis are important to improve outcomes. This pilot study examines the potential for metabolic profiling to aid the diagnosis in critical care.In this prospective observational study ventilated...

article

Effects of Time on Urinary Metabolic Signatures in Inflammatory Bowel Disease

Lucy C. Hicks, Sam T. Powles, Jonathan R. Swann, Leo W. Chong, more

Gastroenterology > 2017 > 152 > 5(S1) > S611-S612

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INFONA - science communication portal

Search results for: Elaine Holmes

Implementation of pure shift ¹H NMR in metabolic phenotyping for structural information recovery of biofluid metabolites with complex spin systems

Odd Chain Fatty Acids Are Not Robust Biomarkers for Dietary Intake of Fiber

Enhanced Microbial Bile Acid Deconjugation and Impaired Ileal Uptake in Pregnancy Repress Intestinal Regulation of Bile Acid Synthesis

Autotaxin, bile acid profile and effect of ileal bile acid transporter inhibition in primary biliary cholangitis patients with pruritus

The effects of kisspeptin on β‐cell function, serum metabolites and appetite in humans

PC232. Metabolic Profiling of High-Risk Carotid Atherosclerosis

Improved physiology and metabolic flux after Roux-en-Y gastric bypass is associated with temporal changes in the circulating microRNAome: a longitudinal study in humans

The C6H6 NMR repository: An integral solution to control the flow of your data from the magnet to the public

24 - A Novel Route to Controlling Clostridioides Difficile Growth via Short Chain Fatty Acid and Bile Acid Modulation

Deep Vein Thrombosis Exhibits Characteristic Serum and Vein Wall Metabolic Phenotypes in the Inferior Vena Cava Ligation Mouse Model

126 - South Asian Ethnicity Drives Differences in Microbial and Metabolic Profiling in a Newly Diagnosed Ulcerative Colitis Cohort

Mo1945 - Effect of Bowel Purgatives on Urinary Metabolic Profiling Associated with the Faecal Microbiome

CHANGES IN METABONOMIC PROFILE DURING PEANUT-INDUCED ANAPHYLAXIS AND CORRELATION WITH SYMPTOM

Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin

Rifaximin in non‐alcoholic steatohepatitis: An open‐label pilot study

DISCOVERY AND VALIDATION OF MULTIMODAL BIOMARKER SIGNATURES RELATING TO ALZHEIMER'S DISEASE PATHOLOGY AND PROGRESSION

The Plasma and Serum Metabotyping of Hepatocellular Carcinoma in a Nigerian and Egyptian Cohort using Proton Nuclear Magnetic Resonance Spectroscopy

Longitudinal analysis of serum oxylipin profile as a novel descriptor of the inflammatory response to surgery

Metabolic Profiling in Patients with Pneumonia on Intensive Care

Effects of Time on Urinary Metabolic Signatures in Inflammatory Bowel Disease

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