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This article describes fabrication of a two‐component extracellular matrix (ECM) in which one component acts as a stable structural element and another component gels or dissolves reversibly (a modulatory component). Using a composite collagen‐alginate ECM, reversible crosslinking of the alginate (the modulatory component) via application of calcium or citrate modulates cell mobility in a 3D collagen...
The front cover image depicts a two‐component extracellular matrix (ECM) in which one component acts as a stable structural element (which supports cell attachment and migration) and another component gels or dissolves reversibly (a modulatory component). Samuel K. Sia and co‐workers show on p. 686 that by dynamically adding or removing crosslinks in the modulatory component, properties of the composite...
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