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Mechanical stress plays an essential role in bone homeostasis. Although mechanotransduction-induced de novo gene expression is required for bone remodeling, the molecular mechanism of intracellular signaling, which leads to regulation of gene expression, is not fully understood. Here, we show that JNK and p38 [two stress-responsible mitogen-activated protein kinases (MAPKs)] are activated via ASK1...
Mechanical stress plays a key role in bone remodeling. Previous studies showed that loading of mechanical stretch induces a rapid Ca 2+ influx and subsequent activation of stress-activated protein kinase pathways in osteoblasts. However, the activation mechanism and its significance in bone remodeling have not been fully elucidated. Here we show that TAK1 MAPKKK was activated by cyclic stretch...
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