Background: The serine/threonine kinase glycogen synthase kinase-3β (GSK-3β) is involved in a broad range of cellular processes, including cell proliferation, apoptosis, and inflammation. GSK-3β has been considered to play an important role in the pathogenesis of T2DM and AD, which is activated in both the periphery and central nervous system. However, the upstream and downstream factors and the underlying...
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