Parkinson’s disease is a common, adult-onset neurodegenerative disorder whose pathogenesis is still under intense investigation. Substantial evidence from postmortem human brain tissue, genetic- and toxin-induced animal and cellular models indicates that mitochondrial dysfunction plays a central role in the pathophysiology of the disease. This review discusses our current understanding of Parkinson’s...
There is increasing computational evidence that the exceptionally high vulnerability of dopaminergic neurons in Parkinson’s disease may be due to their unique axonal architecture and resulting metabolic needs. A new experimental study has actually demonstrated this.
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