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Drug-drug interactions are a major concern with triazoles. Azoles are potent metabolic inhibitors and interactions commonly occur via metabolizing enzymes (ie, cytochrome P450 isoenzyme superfamily) or drug transporters (ie, P-glycoprotein). However, the clinical relevance of these interactions may vary upon the azole involved and upon the “target” drug. Azoles may also be under influence of and become...
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