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Based on the high electron transfer rate between the [2Fe-2S] cluster and heme c 1 and the elevation of the redox midpoint potential of iron sulfur protein (ISP) upon binding of certain Qo inhibitors, the binding rate constants of stigmatellin and UHDBT to the cytochrome bc 1 complex were determined using a stopped-flow rapid scanning technique. Assuming that the intramolecular electron...
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